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Individual neurons mix multiple RNA edits of key synapse protein, study finds

A new study finds complexin is a key protein for regulating neural communication. New research finds neurons stochastically generated up to eight different versions of complexin release, which could vary how they communicate with other cells.

Troy littletonSuresh jettiZhuo guanNational institutes of healthPicower institute forCognitive sciencesCell reportsPicower instituteMenicon professorElizabeth brija phdNational institutesMit picower instituteRna editingOmplexin 7aGlutamate releaseEural communication

Research: Individual Neurons Combine Multiple RNA Edits of Synapse Protein

Research: Individual Neurons Combine Multiple RNA Edits of Synapse Protein
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Troy littletonSuresh jettiZhuo guanCognitive sciencesPicower institute forNational institutes of healthCell reportsPicower instituteMenicon professorElizabeth brija phdNational institutes

Individual neurons mix multiple RNA edits of key synapse protein, fly study finds

Individual neurons mix multiple RNA edits of key synapse protein, fly study finds
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Suresh jettiZhuo guanTroy littletonElizabeth brijaCognitive sciencesPicower institute forNational institutes of healthMenicon professorNational institutesPicower institute

Individual neurons mix multiple RNA edits of key synapse protein, fly study finds

Individual neurons mix multiple RNA edits of key synapse protein, fly study finds
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Elizabeth brijaTroy littletonElizabetha brijaPicower institute forPicower instituteCognitive sciencesLittleton labCell reportsMenicon professorComplexinc terminus

Study connects neural gene expression differences to functional distinctions

The Picower Institute for Learning and Memory found that the two closely related neuronal subtypes differed from each other in how they expressed more than 800 genes. By manipulating genes whose expression differed most prominently, the scientists were then able to show how they produced several of the observable differences between the cells.

Charles whittakerNicole aponteTroy littletonKaren cunninghamYulia akbergenovaSuresh jettiNational institutes of healthPicower institute forCognitive sciencesPicower instituteMenicon professorAndres craneNicole aponte santiagoNational institutesPicower institute for learning and memoryEne expression