Polygenic Score News Today

Researchers said the scoring system led to false positives and ‘performed poorly when predicting if a person would develop common diseases.

<p>The new study, published in <em>BMJ Medicine</em>, looked at 926 polygenic risk scores for 310 diseases. It found that, on average, only 11% of individuals who develop disease are identified, while at the same time 5% of people who do not develop the disease test positive. Unaffected people usually outnumber those affected which results in far more false than true positive predictions.</p>

Researchers said the scoring system led to false positives and ‘performed poorly’ when predicting if a person would develop common diseases.

Researchers said the scoring system led to false positives and ‘performed poorly’ when predicting if a person would develop common diseases.

Researchers said the scoring system led to false positives and ‘performed poorly’ when predicting if a person would develop common diseases.

A substantial proportion of the adult US population with type 2 diabetes (T2D) are undiagnosed, calling into question the comprehensiveness of current screening practices, which primarily rely on age, family history, and body mass index (BMI). We hypothesized that a polygenic score (PGS) may serve as a complementary tool to identify high-risk individuals. The T2D PGS maintained predictive utility after adjusting for family history and combining genetics with family history led to even more impro...