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IJMS | Free Full-Text | Myogenetic Oligodeoxynucleotide Induces Myocardial Differentiation of Murine Pluripotent Stem Cells

An 18-base myogenetic oligodeoxynucleotide (myoDN), iSN04, acts as an anti-nucleolin aptamer and induces myogenic differentiation of skeletal muscle myoblasts. This study investigated the effect of iSN04 on murine embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). In the undifferentiated state, iSN04 inhibited the proliferation of ESCs and iPSCs but did not affect the expression of pluripotent markers. In the differentiating condition, iSN04 treatment of ESCs/iPSCs from day ...
United Kingdom United States Baden Wüberg San Diego Jackson Immunoresearch Wayne Rasband
Source: mdpi.com

Frontiers | Two Hidden mtDNA-Clades of Crown-of-Thorns Starfish in the Pacific Ocean

Recurring outbreaks of crown-of-thorns starfish (COTS) severely damage healthy corals, especially in the Western Pacific Ocean. To obtain a better understanding of population genetics of COTS and historical colonization across the Pacific Ocean, complete mitochondrial genomes were sequenced from 243 individuals collected in 11 reef regions. Our results indicate that Pacific COTS (Acanthaster cf. solaris) comprise two major clades, an East-Central Pacific (ECP) clade and a Pan-Pacific (PP) clade,...
Pacific Ocean French Polynesia General French Polynesia United States Red Sea Djibouti General

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High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages

Excessive inflammation is a characteristic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, particularly in patients that are hospitalized with coronavirus disease 2019 (COVID-19). Here, Hoepel et al. investigated how human antibodies specific to SARS-CoV-2 spike protein may contribute to exacerbated inflammation. The authors found that spike protein–specific antibodies from patients with COVID-19 who were hospitalized had altered glycosylation, with an enrichment in ...
Noord Holland United States Miltenyi Biotec U Cytech Biosciences Melinda Gates Foundation Dutch Federation Of University Medical Centers

IDT Acquires Swift Biosciences, a Pioneer in the Development of Next-Generation Sequencing (NGS) Library Preparation Genomics Kits for Academic, Translational, and Clinical Research

Posted on 138 Integrated DNA Technologies (IDT), a leading comprehensive genomics solutions provider, announced today the acquisition of Swift Biosciences, a pioneer in the development of Next-Generation Sequencing (NGS) library preparation genomics kits for academic, translational, and clinical research. IDT is a leader in developing and manufacturing nucleic acid products for academic and commercial research, agriculture, medical d...
Ann Arbor United States North Carolina Research Triangle Park San Diego Region Flamande

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SARS-CoV-2 Real-Time RT-PCR Assay The PerkinElmer SARS-CoV-2 Real-Time RT-PCR assay is CE-IVD (in vitro diagnostic) marked and intended for qualitative detection of nucleic acid from the SARS-CoV-2 virus in human oropharyngeal swab, nasopharyngeal swab, and saliva specimens from individuals suspected of having COVID-19 or from asymptomatic carriers. The assay target two specific genomic regions of SARS-CoV-2: the nucleocapsid (N) gene and ORF1ab; so mutations in spike protein, as seen in the B....
Sureseq Pan Amazon Web Services Oxford Gene Technology Dna Library Preparation Gene Technology Sureseq Pan Myeloid

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