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Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal

Decades of previous efforts to develop renal-sparing polyene antifungals were misguided by the classic membrane permeabilization model1. Recently, the clinically vital but also highly renal-toxic small-molecule natural product amphotericin B was instead found to kill fungi primarily by forming extramembraneous sponge-like aggregates that extract ergosterol from lipid bilayers2–6. Here we show that rapid and selective extraction of fungal ergosterol can yield potent and renal-sparing polyen...
South Korea Fungal Priority Pathogens List To Guide Research Mcgraw Hill Laboratory Standards Institute Public Health Action World Organization Clinical Pharmacology
Source: nature.com

The impact of inpatient bloodstream infections caused by antibiotic-resistant bacteria in low- and middle-income countries: A systematic review and meta-analysis

Kasim Allel and colleagues systematically review published literature from low- and middle-income countries and meta-analyse data extracted from 109 articles to explore the impact of bloodstream infections caused by antibiotic-resistant bacteria.
Pais Vasco Royal Society Of Tropical Medicine World Bank Caribbean Health Sciences Literature Lilacs World Health Organization Index Medicus
Source: plos.org

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