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Neoadjuvant chemotherapy may be optimal first-line treatment in advanced ovarian cancer

Increased use of neoadjuvant chemotherapy appeared associated with improvements in short-term mortality without sacrificing long-term survival in ovarian cancer, according to a comparative effectiveness research study in JAMA Oncology.The difference-in-differences analysis compared cancer programs with high use vs. low use of neoadjuvant chemotherapy (NACT), as researchers understood the
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Expert gives pearls for secondary IOL implantation in aphakic eyes

NEW YORK – Certain IOLs are better suited to sutured or sutureless secondary IOL implantation techniques in aphakic eyes, according to a presenter at OSN New York Retina. Anton Orlin, MD, said that while anterior chamber IOLs can be very effective, they can lead to some complications, including corneal decompensation and iritis, particularly in patients with a history of anterior
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Access to scalp cooling for chemotherapy-induced alopecia prevention differs by geography

Access to scalp cooling therapy for patients undergoing chemotherapy is affected by geographic location, according to a study.“Chemotherapy-induced alopecia (CIA) is one of the most stigmatized and psychologically challenging experiences for patients undergoing cancer treatment, with some women refusing chemotherapy because of the risk of alopecia,” Sean Singer, MD, of the department
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Most LAI antipsychotic prescribers report pandemic has not affected prescribing

Most frequent prescribers of long-acting injectable antipsychotics reported no changes in prescribing during the COVID-19 pandemic, according to results of a health care provider survey study presented at Psych Congress.However, certain factors did affect long-acting injectable (LAI) antipsychotic prescribing among some providers.
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ISCHEMIA results may only apply to subset of real-world PCI population

According to an analysis in JACC: Cardiovascular Interventions, the results of the ISCHEMIA trial of invasive vs. conservative treatment of stable ischemic heart disease may only be applicable to one-third of the real-world PCI population.“Guidelines recommend revascularization for patients with stable ischemic heart disease (SIHD) in the appropriate clinical context to reduce the risk of
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Fluoroquinolone use varies significantly based on provider age

Fluoroquinolone use decreased between 2015 and 2016 due in part to FDA advisories. However, their use still varies significantly based on provider age and other characteristics, according to a study. “Frequently used fluoroquinolones have been subject to increasing safety concerns and regulatory alerts,” Siddhi Pramod Umarje, PharmD, ScM, a graduate research assistant at the Johns
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COVID-19 vaccination more protective than previous infection, study finds

Another study has found that COVID-19 vaccination is more protective than a previous infection.In the study, which included more than 7,000 people in nine states, unvaccinated people who were recently infected with SARS-CoV-2 were more than five times likelier to get COVID-19 than people who were fully vaccinated with a COVID-19 messenger RNA vaccine, according to a report in MMWR.
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Q&A: Navigating COVID-19's disruptions to breast cancer care

Research suggests that the COVID-19 pandemic has disrupted breast cancer screening, diagnosis and treatment. For example, a study conducted in Massachusetts revealed that the screening mammogram rate in April 2020 was down 98% from the rate in April 2019. Another study of women across the United States that made the same comparison showed a 90.8% drop.
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Achieving clinician-defined target IOP affects change in visual field

Patients with glaucoma who did not achieve clinician-defined target IOP had more rapid visual field worsening, according to data published in Ophthalmology. While other studies have explored the effects of achieving prespecified target IOP, few have studied the clinician-set target.
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Cardiovascular warnings common but slower to be issued for FDA-approved cancer drugs

Although more than 25% of contemporary FDA-approved cancer therapies required cardiovascular warnings, post-marketing issuance of the warnings trailed clinical approval by several years, according to a research letter in JAMA Oncology.“Our findings suggest the need for increased vigilance to potentially limit cardiotoxic events, such as arrhythmias. This is especially important as many
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