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Exercise confers minor changes in 3 gut microbiome genera in adults with obesity

An 8-week exercise intervention was associated with improvements in insulin sensitivity and visceral adiposity in adults with obesity, with modest changes observed in three gut microbiome genera, according to study findings. “This study demonstrated that an 8-week exercise intervention in humans with obesity causes significant improvements in cardiovascular and metabolic health in the
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Source: healio.com

Tafamidis stabilizes transthyretin in cohort with transthyretin amyloid cardiomyopathy

According to a non-trial, published in JACC: CardioOncology, in unselected patients, serum transthyretin change after tafamidis initiation for transthyretin amyloid cardiomyopathy may serve as a surrogate measure of drug efficacy.“Transthyretin (TTR)-derived amyloid (ATTR) cardiomyopathy is an increasingly recognized disease characterized by infiltration of the myocardium with either
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Source: healio.com

Higher white blood cell count tied to genetic depression risk

Increased white blood cell count appeared linked to increased depression polygenic scores, with a potential bidirectional association, according to results of a genetic association study published in JAMA Psychiatry. “We’ve known for a while now that there is a link between depression and inflammation, but what we didn’t know was whether inflammation led to depression or
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Source: healio.com

Ramadan fasting beneficial for BP independent of weight, other factors

Fasting during the month of Ramadan can have beneficial effects on BP independent of weight changes, fat mass and total body water, results from an observational study found.The study, published in the Journal of the American Heart Association, sought to determine the health effects of the drastic change in lifestyle that millions of people undergo during Ramadan. The publication consisted of a
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Source: healio.com

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Pediatric patients experience higher eosinophilic esophagitis endoscopic findings

Compared with adult patients who more frequently experienced delayed eosinophilic esophagitis diagnosis, pediatric patients had higher endoscopic findings of the disease with increased eosinophils detected during esophageal biopsy. “Incidence and prevalence of EoE has sharply increased in the last few years. Currently, EoE is the most frequent eosinophilic gastrointestinal disorder with a
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Source: healio.com

Systemic corticosteroid use continues in some patients with CSC despite risks

Patients with central serous chorioretinopathy may be prescribed systemic corticosteroids despite evidence showing that steroids can contribute to the disease, according to data published in Ophthalmology. In a retrospective analysis, Amee D. Azad, MD, MS, and colleagues investigated the frequency of systemic corticosteroid prescriptions before and after diagnosis of central serous
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Source: healio.com

FDA approves Cyltezo as first interchangeable biosimilar for inflammatory disease

The FDA has designated Cyltezo the first approved interchangeable biosimilar to treat certain inflammatory diseases, allowing pharmacists to substitute it for Humira without the need for the prescriber to alter the prescription. According to the FDA, Cyltezo (adalimumab-adbm, Boehringer Ingelheim) is just the second interchangeable biosimilar product approved by the agency, and the first
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Source: healio.com

Physical activity crucial for lowering CV risk, maintaining weight loss

Regular physical activity is a critical part of maintaining weight loss, and providers should explore different methods to motivate their patients to be more active, according to three speakers at the Cardiometabolic Health Congress.“In our current environment, it is impossible for a population to have low rates of physical activity and low rates of obesity,” James O. Hill, PhD,
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