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Decline of onset-to-diagnosis interval and its impacts on clinical outcome of COVID-19 in China: a nation-wide observational study | BMC Infectious Diseases

To quantitatively assess the impact of the onset-to-diagnosis interval (ODI) on severity and death for coronavirus disease 2019 (COVID-19) patients. This retrospective study was conducted based on the data on COVID-19 cases of China over the age of 40 years reported through China’s National Notifiable Infectious Disease Surveillance System from February 5, 2020 to October 8, 2020. The impacts of ODI on severe rate (SR) and case fatality rate (CFR) were evaluated at individual and population levels, which was further disaggregated by sex, age and geographic origin. As the rapid decline of ODI from around 40 days in early January to < 3 days in early March, both CFR and SR of COVID-19 largely dropped below 5% in China. After adjusting for age, sex, and region, an effect of ODI on SR was observed with the highest OR of 2.95 (95% CI 2.37‒3.66) at Day 10–11 and attributable fraction (AF) of 29.1% (95% CI 22.2‒36.

Chinese centerR foundation for statistical computingTreatment program for novel coronavirus infected pneumoniaNational health commissionTreatment programNovel coronavirus infectedTreatment schemeNew coronavirus infectedHealth commissionDisease controlStatistical computing

Cureus | Changes in the Emergency General Surgery Operations in the Setting of COVID-19 and Impact of Strategy of Non-Operative Management on Outcomes in Acute Appendicitis

Cureus | Changes in the Emergency General Surgery Operations in the Setting of COVID-19 and Impact of Strategy of Non-Operative Management on Outcomes in Acute Appendicitis
cureus.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from cureus.com Daily Mail and Mail on Sunday newspapers.

United kingdomWorld health organizationR foundation for statistical computingStatistical computingSurgery versus conservative

Age–period–cohort analysis of pulmonary tuberculosis reported incidence, China, 2006–2020 | Infectious Diseases of Poverty

Tuberculosis (TB) poses a severe public health challenge in China and worldwide. This study evaluated the effects of age, period, and birth cohort on reported incidence trends of TB based on population and refined the characteristics of high-risk groups. Aggregate data that reported pulmonary tuberculosis (PTB) cases from China Tuberculosis Management Information System (TBIMS) from 2006 to 2020 were used to analyze effect coefficients through the age–period–cohort (APC) model based on intrinsic estimator (IE) method, and converted them into relative risk (RR) to estimate trends. A total of 14.82 million cases of PTB were reported in China from 2006 to 2020, showing a continuous downward trend. The reporting rate increased with age by age group, with 70–74 years old being 2–3 times higher than that in 20–24 years old. APC analysis model showed that age effects were bimodal in 20–24 years old [RR = 2.29,

Inner mongoliaNei mongolManagement information system of the chinese centerNational bureau of statisticsR foundation for statistical computingIntegrated management information systemChinese centerDisease preventionChinese population censusNational bureauStatistical computing

Lifetime risk of developing diabetes in Chinese people with normoglycemia or prediabetes: A modeling study

Xinge Zhang and colleagues estimate remaining lifetime risk of diabetes and life years spent with diabetes in Chinese people with normoglycaemia and prediabetes.

United statesHong kongUniversity of hong kongHong kong generalUnited kingdomDa qingMerck seronoMonte carloAstra zenecaClaudia langenbergTricida incInternational classification of diseasesNational death indexNational health interviewBoehringer ingelheimAmerican diabetes association

Prevention of venous thromboembolic events in patients with lower leg immobilization after trauma: Systematic review and network meta-analysis with meta-epsidemiological approach

Delphine Douillet and colleagues investigate the benefit/risk ratio of thromboprophylaxis for patients with leg immobilization after trauma.

Pays de la loireUnited statesLeo pharmaMarc samamaDaiichi sankyoDonalda redelmeierCochrane roEli lillyInternational society on thrombosisInternational congress on thrombosisUniversity of torontoCochrane libraryBayer healthBristol myers squibbR foundation for statistical computingPreferred reporting items