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Objective We explored the comparative effectiveness of available therapies for chronic pain associated with temporomandibular disorders (TMD). Design Systematic review and network meta-analysis of randomised clinical trials (RCTs). Data sources MEDLINE, EMBASE, CINAHL, CENTRAL, and SCOPUS were searched to May 2021, and again in January 2023. Study selection Interventional RCTs that enrolled patients presenting with chronic pain associated with TMD. Data extraction and synthesis Pairs of reviewer...

A systematic review finds that consuming at least 60 grams of nuts daily significantly enhances male fertility by improving sperm vitality, motility, and morphology, while evidence for nut consumption's impact on female fertility remains limited.

In a recent study published by the European Center for Disease Prevention and Control, researchers assessed the prevalence of post-coronavirus disease 2019 (COVID-19) condition symptoms.

As cannabidiol (CBD) use rises, high quality randomized clinical trials are needed to determine if anti-inflammatory benefits of CBD for heart disease seen in preclinical data will work in a real-world setting, according to research presented at ACC Latin America 2022 Together with CardioAcademic.

Targeting apoptosis in cancer therapy has become increasingly popular, and there has been an increasing debate on whether apoptosis should be one of the main targets of therapy in cancer management. This study demonstrates the definition of apoptosis, the signaling pathways, and the pathogenesis behind it. We also show the correlation between apoptosis and cancer and how cancer can evade apoptosis to develop resistance to therapy. In addition, we illustrate the efficacy of adding pro-apoptotic t...

A new study reports that in children and adolescents without glucocorticoid deficiency, circulating cortisol levels were higher during acute illnesses.

On January 26, 2022, the SEC issued a release (the "Release") proposing amendments to Form PF (the "Proposal"). The Proposal includes: (i) new current reporting requirements for large hedge fund advisers...

Abstract Background: Spontaneous bacterial peritonitis (SBP) is one of the most common infectious diseases in patients with cirrhosis and is associated with serious prognosis. A prevailing dogma posits that SBP is exacerbated by the frequent use of proton pump inhibitors (PPIs). Aims: To re-assess the association between PPIs use and SBP incidence with larger and better-quality data. Method: The studies were identified by searching Proquest, Medline, and Embase for English language articles pub...