Cancer Tricks Immune Cells, Immunotherapy Can Take Advantage
A paper published today in Nature shows how chemicals in the areas surrounding tumors known as the tumor microenvironment subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy.
The study was conducted by a team of scientists at the University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center, led by Pitt associate professor of immunology Greg Delgoffe. By disrupting the effect of the tumor microenvironment on immune cells in mice, the researchers were able to shrink tumors, prolong survival and increase sensitivity to immunotherapy.
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IMAGE: Cancer evades the immune system by feeding the T cells that protect the tumor and starving the T cells that would attack. view more
Credit: UPMC, created with BioRender.com
PITTSBURGH, Feb. 15, 2021 - A paper published today in
Nature shows how chemicals in the areas surrounding tumors known as the tumor microenvironment subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy.
The study was conducted by a team of scientists at UPMC Hillman Cancer Center and the University of Pittsburgh School of Medicine, led by Greg Delgoffe, Ph.D., Pitt associate professor of immunology. By disrupting the effect of the tumor microenvironment on immune cells in mice, the researchers were able to shrink tumors, prolong survival and increase sensitivity to immunotherapy.