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Frontiers | Tilapia Lake Virus-Induced Neuroinflammation in Zebrafish: Microglia Activation and Sickness Behavior

In mammals, the relationship between the immune system and behavior is widely studied. In fish, however, the knowledge concerning the brain immune response and behavioral changes during brain viral infection is very limited. To further investigate this subject, we used the model of tilapia lake virus (TiLV) infection of zebrafish (Danio rerio), which was previously developed in our laboratory. We demonstrated that TiLV persists in the brain of adult zebrafish for at least 90 days, even when the ...
United States Baden Wüberg Noord Brabant Novoab Nodavirus Albert Willemsen Noldus Oreochromis Niloticus

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Frontiers | Review: Insights on Current FDA-Approved Monoclonal Antibodies Against Ebola Virus Infection

1 Abstract The devastating Ebola outbreak in West Africa in 2013-2016 accelerated the progress of several medical countermeasures (MCMs) against Ebola virus disease (EVD). Several IPs were used during that outbreak, but no conclusion on efficacy could be drawn. Only the Randomized Controlled Trial (RCT) on ZMapp was promising but inconclusive. More recently, during the second largest Ebola outbreak in North Kivu and Ituri provinces, Democratic Republic of the Congo (DRC), four IPs (Remdesivir, R...
Democratic Republic Of The Congo Democratic Republic Of The General Bas Congo Virion Glycoproteins Nat Microbiol Ridgeback Biotherapeutics

What's behind the global rise in short-sightedness?

Lancet 2012;379(9827):1739–48. 2. Williams KM, Bertelsen G, Cumberland P, et al. Increasing prevalence of myopia in Europe and the impact of education. Ophathalmology 2015;122(7):1489–97. 3. Huang HM, Chang DS, Wu PC. The association between near work activities and myopia in children–a systematic review and meta-analysis. PLoS One 2015;10(10):e0140419. 4. Ip JM, Rose KA, Morgan IG, et al. Myopia and the urban environment: Findings in a sample of 12-year-old Australian school chil...
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