Single Molecule News Today

-- Pacific Biosciences of California has an average rating of outperform and price targets ranging from $8 to $20, according to analysts polled by Capital IQ. Price: 9.12, Change: +0.26, Percent...

Throughout 2024, the Biodesign Institute is celebrating 20 years of nature-inspired solutions for challenges in health, sustainability and security.

Therapeutic candidates and patient samples can be analyzed ‘in a fraction of the time it would normally take’ thanks to newly patented single-molecule imaging technology.

Therapeutic candidates and patient samples can be analyzed ‘in a fraction of the time it would normally take’ thanks to newly patented single-molecule imaging technology.

DNA replication is essential to successful cell proliferation. Inheritance of traits during cell propagation relies on the accurate duplication of the parental double-stranded DNA (dsDNA) to form two identical daughter copies. This process is carried out by a multi-protein complex referred to as the replisome. Decades of investigations using the model Escherichia coli (E. coli) replisome have provided an overall picture of the process of DNA replication initiation, elongation and termination. Ho...

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Faithful DNA replication is essential for all life. A multi-protein complex called the replisome contains all the enzymatic activities required to facilitate DNA replication, including unwinding parental DNA and synthesizing two identical daughter molecules. Faithful DNA replication can be challenged by both intrinsic and extrinsic factors, which can result in roadblocks to replication, causing incomplete replication, genomic instability, and an increased mutational load. This increased mutation...

Observing the processes of life that occur in all cellular organisms at the level of single molecules has allowed a deeper understanding of the dynamic processes taking place in complex biological systems. There has been a strong growth in the application of molecular biophysics to visualize in real time the behaviour of single molecules within a reaction, transforming our perception of the molecular processes that occur within a cell. A multitude of proteins participates across the genome to su...

The molecular mechanisms that support life depend on the fate of small populations of molecules. The functions of biomolecules, however, are traditionally characterised through bulk-phase biochemical methods that only report on ensemble averages. Such methods are not sensitive to population heterogeneity or short-lived reaction intermediates. Single-molecule methods that allow for the direct observation of individual molecules have significantly advanced our understanding of biology in the past ...

R-loop proteins present a stable and robust blockade to the progression of a DNA replication fork during S-phase. The consequences of this block can include mutagenesis and other irreversible chromosomal catastrophes, causing genomic instability and disease. As such, further investigation into the molecular mechanisms underlying R-loop protein resolution is warranted. The critical role of non-replicative accessory helicases in R-loop protein resolution has increasingly come into light in recent ...