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Panitumumab vs Bevacizumab Added to Standard First-line Chemotherapy and Overall Survival Among Patients With RAS Wild-type, Left-Sided Metastatic Colorectal Cancer: A Randomized Clinical Trial | Colorectal Cancer | JAMA

This randomized clinical trial assesses the effect of adding panitumumab vs bevacizumab to standard first-line chemotherapy on overall survival among patients w
United States EtelÀuomen LÀi Solasia Pharma Marko Rehn Takayuki Yoshino Merck Serono

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Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial | Lifestyle Behaviors | JAMA

This clinical trial compares the efficacy and adverse event profiles of once-weekly subcutaneous semaglutide, 2.4 mg, vs once-daily subcutaneous liraglutide, 3.
EtelÀuomen LÀi United States Domenicam Rubino Jenny Craig Novmeta Pharma Sophie Walton

Effect of Argatroban Plus Intravenous Alteplase vs Intravenous Alteplase Alone on Neurologic Function in Patients With Acute Ischemic Stroke: The ARAIS Randomized Clinical Trial | Cerebrovascular Disease | JAMA

This randomized clinical trial examines the efficacy of argatroban plus altepase for acute ischemic stroke within 4.5 hours from onset.
Long Wang Hui Sheng Chen National Institutes Of Health Stroke Scale National Natural Science Foundation Of China Department Of Neurology Group Information

Effect of Early High-Flow Nasal Oxygen vs Standard Oxygen Therapy on Length of Hospital Stay in Hospitalized Children With Acute Hypoxemic Respiratory Failure: The PARIS-2 Randomized Clinical Trial | Critical Care Medicine | JAMA

This randomized clinical trial compares the effect of early high-flow oxygen therapy vs standard oxygen therapy on length of hospital stay in children with acut
Western Australia New Zealand France General Spring Hill New South Wales Christopher Seymour

Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial | Critical Care Medicine | JAMA

This randomized clinical trial assesses the effect of selective decontamination of the digestive tract compared with standard care on in-hospital mortality amon
New Zealand General New Zealand France General New South Wales United Kingdom Northern Ireland

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