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Dynamic Vapor Sorption for the Determination of Moisture-Induced Glass Transition in an Amorphous Pharmaceutical

A new method to determine the onset relative humidity for a glass transition in an amorphous material was developed using the DVS. Water vapour can act as a plasticising agent in amorphous materials, causing a recrystallisation event below the glass transition temperature. This method calculates the threshold relative humidity for this moisture induced glass transition at a particular temperature.
Surface Measurement Systems Ltd Sponsored Content Surface Measurement Systems Ltdoct Measurement Systems Ltd Dynamic Vapor Sorption Inverse Gas Chromatography

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Use of Optical Microscopy for the Investigation of Dried Milk Powders under Varying Humidity Conditions

The effects of humidity are evident in the stability and shelf-life of a variety of materials, formulations, and processing behaviour, especially food materials. This article discusses the advantages of a direct comparison method of three similar dried milk samples under varying humidity conditions, using optical microscopy in conjunction with the GenRH-A accessory and Mcell from Surface Measurement Systems.
Surface Measurement Systems Ltd Sponsored Content Surface Measurement Systems Ltdoct Surface Measurement Systems Measurement System Three Milk Powder

Monitoring Hydration State Changes of Anti-Inflammatory Agents Using Raman Spectroscopy

In drug research and development, the effect that the hydration state of active pharmaceutical ingredients (APIs) has on crystallinity is an important consideration. Variations in crystallinity influence the stability, solubility, bio-availability, and dissolution rate of the drug. Therefore, knowing the effect that humidity has on the stability of different states is important, from both a regulatory and safety standpoint.
Paul Young J Pharm Pharmacol Department Of Pharmacology Surface Measurement Systems Ltd University Of Bath Sponsored Content

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