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 E-Mail Scientists have produced a comprehensive roadmap of muscle aging in mice that could be used to find treatments that prevent decline in muscle mobility and function, according to a report published today in eLife. The study reveals which molecules in the muscle are most significantly altered at different life stages, and shows that a molecule called Klotho, when administered to mice in old, but not very old, age, was able to improve muscle strength. Age-related loss of skeletal muscle mass and function - called sarcopenia - is associated with loss of mobility and increased risk of falls. Yet, although scientists know how sarcopenia affects the appearance and behaviour of muscle tissues, the underlying molecular mechanisms for sarcopenia remain poorly understood. Current treatments for sarcopenia largely involve prescribing physical activity or dietary modifications, and these have shown moderate success.

United statesFabrisia ambrosioSruthi sivakumarZachary clemensAnastasia gorelovaEmily packerAlice wallenberg foundationOccupational healthUniversity of pittsburghDepartment of physical medicineDepartment of environmentalMax planck societyHoward hughes medical instituteDoctoral studentAssociate professorPhysical medicine