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Frontiers | Genome-Wide Association Analysis Reveals Genetic Loci and Candidate Genes for Chest, Abdominal, and Waist Circumferences in Two Duroc Pig Populations

Chest circumference (CC), abdominal circumference (AC), and waist circumference (WC) are regarded as important indicators for improving economic traits because they can reflect the growth and physiological status in pigs. However, the genetic architecture of CC, AC, and WC is still elusive. Here, we performed single-trait and multi-trait genome-wide association studies (GWASs) for CC, AC, and WC in 2206 American origin Duroc (AOD) and 2082 Canadian origin Duroc (COD) pigs. As a result, one novel...
Baden WĂŒberg United States New York Nat Genet Coheni Pearson J Clin Nutr

Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial | Critical Care Medicine | JAMA

This randomized clinical trial compares the effect of continuous positive airway pressure or high-flow nasal oxygen vs conventional oxygen therapy on clinical o
United Kingdom EtelÀuomen LÀi Brighton And Hove East Sussex West Midlands United Kingdom General

Combination of tucatinib and neural stem cells secreting anti-HER2 antibody prolongs survival of mice with metastatic brain cancer

Brain metastases are among the most severe complications of systemic breast cancer, and overexpression of the human epidermal growth factor receptor 2 (HER2) in breast cancer cells increases the incidence of brain metastases in patients. In this study, we engineered the human-derived, tumor cell tropic neural stem cells LM-NSC008 (LM008) to continuously secrete antibodies against HER2. These anti-HER2 antibodies impaired tumor cell proliferation by inhibiting the PI3K-Akt signaling pathway in HE...
United States Harvard University Glo Promega Trastuzumab Herceptin Yu Han Tucatinib Tukysa
Source: pnas.org

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Vaccine effectiveness against SARS-CoV-2 infection, hospitalization, and death when combining a first dose ChAdOx1 vaccine with a subsequent mRNA vaccine in Denmark: A nationwide population-based cohort study

Mie Agermose Gram and co-workers study the effectiveness of heterologous SARS-CoV-2 vaccine combinations in the Danish population.
Netherlands General United Kingdom Oxford Astrazeneca Mirjamee Kretzschmar Danish Data Protection Agency Danish Health Data Authority
Source: plos.org

Effect of Use of a Bougie vs Endotracheal Tube With Stylet on Successful Intubation on the First Attempt Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial | Anesthesiology | JAMA

This multicenter randomized clinical trial assesses the effect of use of a tracheal tube introducer vs an endotracheal tube with stylet on successful intubation
District Of Columbia United States Christopher Seymour Vanderbilt University Medical Center Goldfinch Health Department Of Defense

Transpiration Rates of Urban Trees in Different Management Contexts

Urbanization has led to drastic changes to hydrologic systems due to the replacement of vegetated areas with impervious surfaces, modification of overall water and sediment budgets, and a decrease in stream complexity. Ponte, S. et al.'s study identifies whether transpiration rates of urban trees of
Chesapeake Bay United States Ellicott City State Of Maryland EtelÀuomen LÀi Kanta Hame Region

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