Page 14 - Statistical Computing News Today

Purpose: Asthma and chronic obstructive pulmonary disease (COPD) are complex and heterogeneous inflammatory diseases. We sought to investigate distinct disease profiles based on clinical, cellular and molecular data from patients with mild-to-moderate obstructive pulmonary diseases. Patients and Methods: Patients with mild-to-moderate allergic asthma (n=30) and COPD (n=30) were prospectively recruited. Clinical characteristics and induced sputum were collected. In total, 35 mediators were asses...

Department of Forest and Conservation Sciences, Faculty of Forestry, University of British Columbia, Vancouver, BC, Canada In the 2017 and 2018, 2.55 million hectares burned across British Columbia, Canada, including unanticipated large and high-severity fires in many dry forests. To transform forest and fire management to achieve resilience to future megafires requires improved understanding historical fire frequency, severity, and spatial patterns. Our dendroecological reconstructions of 35 p...

SARS-CoV-2 variants with multiple spike mutations enable increased transmission and antibody resistance. Here, we combine cryo-EM, binding and computational analyses to study variant spikes, including one that was involved in transmission between minks and humans, and others that originated and spread in human populations. All variants showed increased ACE2 receptor binding and increased propensity for RBD up states. While adaptation to mink resulted in spike destabilization, the B.1.1.7 (UK) sp...

2Institute of Environmental Sciences, Koblenz-Landau University, Landau, Germany 3Swiss Federal Institute for Forest, Snow, and Landscape Research (WSL), Birmensdorf, Switzerland Combined effects of climate change and increasing anthropogenic water demand have increased and extended dry period occurrences in rivers worldwide. Riverbed drying can significantly affect sediment microorganisms, crucial drivers of biogeochemical processes in lotic systems. In this study, we evaluated how sediment ba...

In a Mendelian randomization analysis, Parag Gajendragadkar and colleagues investigate associations between genetically-predicted EEG parameters and risk of atrial fibrillation among UK Biobank participants.

Research Article Associations of treated and untreated human papillomavirus infection with preterm delivery and neonatal mortality: A Swedish population-based study Johanna Wiik , Roles Data curation, Formal analysis, Methodology, Supervision, Writing – review & editing Affiliations Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden, Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, Univ...

Background The ongoing transmission of the Middle East respiratory syndrome coronavirus (MERS-CoV) in the Middle East and its expansion to other regions are raising concerns of a potential pandemic. An in-depth analysis about both population and molecular epidemiology of this pathogen is needed. Methods MERS cases reported globally as of June 2020 were collected mainly from World Health Organization official reports, supplemented by other reliable sources. Determinants for case fatality and spa...

10. World Medical Association.  World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects.  11. Desai  RJ, Franklin  JM.  Alternative approaches for confounding adjustment in observational studies using weighting based on the propensity score: a primer for practitioners.  12. Kimball  A, Hatfield  KM, Arons  M,  et al; Public Health – Seattle & King County; C...

Research Article Circulating tumor DNA dynamics and recurrence risk in patients undergoing curative intent resection of colorectal cancer liver metastases: A prospective cohort study Jeanne Tie , Contributed equally to this work with: Jeanne Tie, Yuxuan Wang Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original dra...

1. Wiersinga  WJ, Rhodes  A, Cheng  AC, Peacock  SJ, Prescott  HC.  Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): a review.  2. Wu  Z, McGoogan  JM.  Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention.  ...