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Mid-old cells are a potential target for anti-aging interventions in the elderly

The biological process of aging is thought to result in part from accumulation of senescent cells in organs. However, the present study identified a subset of fibroblasts and smooth muscle cells which are the major constituents of organ stroma neither proliferative nor senescent in tissues of the elderly, which we termed “mid-old status” cells. Upregulation of pro-inflammatory genes (IL1B and SAA1) and downregulation of anti-inflammatory genes (SLIT2 and CXCL12) were detected in mid-...
Supplementary Data Hallmark Gene Supplementary Movie Associated Secretory Phenotypes
Source: nature.com

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"Author Correction: Universal DNA methylation age across mammalian tiss" by A. T. Lu, Z. Fei et al.

Correction to: Nature Aging, published online 10 August 2023. In the version of Supplementary Data initially published with this article, data were missing from Table S1.13 (Updated AnAge version in Class Mammalia), which now appear in an updated Supplementary Data file in the online version of the article.
Nature Aging Supplementary Data Updated Anage Class Mammalia
Source: uow.edu.au

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