Supplementary Methods News Today

A fundamental and unresolved question in regenerative biology is how tissues return to homeostasis after injury. Answering this question is essential for understanding the etiology of chronic disorders such as inflammatory bowel diseases and cancer1. We used the Drosophila midgut2 to investigate this and discovered that during regeneration a subpopulation of cholinergic3 neurons triggers Ca2+ currents among intestinal epithelial cells, the enterocytes, to promote return to homeostasis. We found ...

Using combined data extracted from 119 studies from 30 countries, Kirsten E. Wiens and colleagues estimate the true burden Vibrio Cholerae positivity.

Migratory songbirds have the remarkable ability to extract directional information from the Earth’s magnetic field1,2. The exact mechanism of this light-dependent magnetic compass sense, however, is not fully understood. The most promising hypothesis focuses on the quantum spin dynamics of transient radical pairs formed in cryptochrome proteins in the retina3–5. Frustratingly, much of the supporting evidence for this theory is circumstantial, largely because of the extreme c...

Banking cryopreserved organs could transform transplantation into a planned procedure that more equitably reaches patients regardless of geographical and time constraints. Previous organ cryopreservation attempts have failed primarily due to ice formation, but a promising alternative is vitrification, or the rapid cooling of organs to a stable, ice-free, glass-like state. However, rewarming of vitrified organs can similarly fail due to ice crystallization if rewarming is too slow or cra...

This report describes CDC findings from the Autism and Developmental Disabilities Monitoring Network for children aged 4 years in 2020.

KEY POINTS The first known diagnosis of SARS-CoV-2 infection in Canada was in a patient in hospital in Toronto on Jan. 25, 2020.[1][1] At the time, few anticipated the intensity and duration of the COVID-19 pandemic, which has presented health systems and governments globally with challenges not

Background: SARS-CoV-2 infection can lead to multisystem inflammatory syndrome in children (MIS-C). We sought to investigate risk factors for admission to the intensive care unit (ICU) and explored changes in disease severity over time. Methods: We obtained data from chart reviews of children younger than 18 years with confirmed or probable MIS-C who were admitted to 15 hospitals in Canada, Iran and Costa Rica between Mar. 1, 2020, and Mar. 7, 2021. Using multivariable analyses, we evaluated whe...

Maximizing and evaluating the impact of test-trace-isolate programs: A modeling study Kyra H. Grantz , Roles Conceptualization, Formal analysis, Methodology, Software, Visualization, Writing – original draft Affiliation Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America Roles Conceptualization, Formal analysis, Methodology, Software, Visualization, Writing – o...

Abstract Human eye color is highly heritable, but its genetic architecture is not yet fully understood. We report the results of the largest genome-wide association study for eye color to date, involving up to 192,986 European participants from 10 populations. We identify 124 independent associations arising from 61 discrete genomic regions, including 50 previously unidentified. We find evidence for genes involved in melanin pigmentation, but we also find associations with genes involved in iri...