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Frontiers | Stiffening of Circumferential F-Actin Bands Correlates With Regenerative Failure and May Act as a Biomechanical Brake in the Mammalian Inner Ear

The loss of inner ear hair cells causes permanent hearing and balance deficits in humans and other mammals, but nonmammals recover after supporting cells (SCs) divide and replace hair cells. The proliferative capacity of mammalian SCs declines as exceptionally thick circumferential F-actin bands develop at their adherens junctions. We hypothesized that the reinforced junctions were limiting regenerative responses of mammalian SCs by impeding changes in cell shape and epithelial tension. Using mi...
United States Noord Holland Zeiss Axiovert Cingulin Zymed Martin Pollak Kos White Leghorn

Neuronal Imaging for Central Nervous Systems Drugs

Neuronal Imaging for Central Nervous Systems Drugs Sponsored by Photon etcJul 27 2018 The Biosimulation and Imaging platform for new Central Nervous System drugs (BICNSD) is a 3 year project for the validation and development of a unique service based on biosimulation and imaging using two synergistic platforms. This will boost drug development and discovery through tracking drug candidatesโ€™ actions at molecular and subcellular levels and having a greater understanding of Cent...
Rhenovia Pharma Neurons Paul De Koninck Lab Neurophotonics Centre Of Universit Consortium For Drug Discovery Central Nervous System Professor Paul De Koninck

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