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Alnylam Reports Updated Positive Interim Phase 1 Results for ALN-APP, in Development for Alzheimer's Disease and Cerebral Amyloid Angiopathy

โ€“ First Clinical Study of a Central Nervous System-Administered RNAi Therapeutic Showed Rapid and Robust Target Engagement with Sustained Effect Over 6 Months with a Single Dose โ€“ โ€“ ALN-APP Continues to Demonstrate an Encouraging Clinical Safety and Tolerability Profile โ€“ โ€“ Multiple-dose Portion of Study, Part B, Being Initiated in Approved Regions โ€“
United Kingdom Noord Holland Sharon Cohen Tim Mooney Alzheimer Association International Conference Exchange Commission

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Eisai Alzheimer's Drug Data Show Slowing of Decline But Safety Questions Linger

Eisai has presented and published full data from the Phase 3 clinical trial for its Alzheimerโ€™s disease drug lecanemab, with results showing a statistically significant slowing decline associated with the neurodegenerative disorder. While an accelerated approval decision is expected in early 2023, the latest trial data are key because they represent the confirmatory study that could support an application for full FDA approval.
San Francisco United States Ivan Cheung Van Dyck Chrisopher Van Dyk Sharon Cohen

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