Van Molle News Today

Targeted protein degradation is a pharmacological modality that is based on the induced proximity of an E3 ubiquitin ligase and a target protein to promote target ubiquitination and proteasomal degradation. This has been achieved either via proteolysis-targeting chimeras (PROTACs)—bifunctional compounds composed of two separate moieties that individually bind the target and E3 ligase, or via molecular glues that monovalently bind either the ligase or the target1–4. Here, using orthog...

An open-letter of complaint to the Director-General of the World Health Organization, Dr. Margaret Chan chanm@who.int Cc:        The Ministry of Health, Labour and Welfare, Japan, www-admin@nhlw.go.jp              Minister of Health, Labour and Welfare, Japan, shiozaki@y-shiozaki.or.jp              Thomas Frieden, Director CDC, tomfrieden@cdc.gov  Vice-Chancellor, Professor Stuart McCutcheon, The University of Auckland, s.mccutcheon@auckland,ac.nz   From: Sin&helli...