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Aortic Stiffening Linked to Alzheimer's Biomarkers

Jun 1, 2021 Associations seen with many CSF measures, but not beta-amyloid Aortic stiffening was associated with cerebrospinal fluid (CSF) markers of neurodegeneration and Alzheimer’s disease, a cross-sectional study found. “Among our oldest participants, age 74 years and older, greater aortic stiffening is associated with in vivo biomarker evidence of neuroinflammation, tau phosphorylation, synaptic dysfunction, and neurodegeneration, but not amyloidosis,” wrote Angela Jefferson, PhD, o...
United States North Carolina United Kingdom Wake Forest University Vanderbilt University Angela Jefferson

PLD3 gene contributes to risk of Alzheimer's disease

 E-Mail IMAGE: This image shows the close relationship between phospholipase D3 and the pathological hallmarks of Alzheimers disease in tissue from the temporal lobe of a human brain. Phospholipase D3, which is... view more  Credit: Matthew Schrag A rare and controversial mutation in the phospholipase D3 (PLD3) protein - previously linked to Alzheimers disease - interferes with PLD3s vital recycling function inside neurons. Matthew Schrag of Vanderbilt University Medical Center and co...
United States Matthew Schrag Vanderbilt University Medical Center National Institute On Vanderbilt Faculty Research Scholars Vanderbilt Memory Alzheimer Center

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