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Maravai LifeSciences Reports Fourth Quarter and Full Year 2023 Financial Results

22.02.2024 - Continued Focus on Expanding Product Portfolio, Market Leadership and InnovationSAN DIEGO, Feb. 22, 2024 (GLOBE NEWSWIRE) - Maravai LifeSciences Holdings, Inc. (Maravai) (NASDAQ: MRVI), a global provider of life science reagents and services to ...
Gaza Strip Maravai Lifesciences Deb Hart Maravai Lifesciences Trey Martin Becky Buzzeo Vector Laboratories Inc

Epigenetic regulation during cancer transitions across 11 tumour types

Chromatin accessibility is essential in regulating gene expression and cellular identity, and alterations in accessibility have been implicated in driving cancer initiation, progression and metastasis1–4. Although the genetic contributions to oncogenic transitions have been investigated, epigenetic drivers remain less understood. Here we constructed a pan-cancer epigenetic and transcriptomic atlas using single-nucleus chromatin accessibility data (using single-nucleus assay for transposase...
United States Featurematrix Signac Rxm Leica Biosystems Mycoalert Lonza Perkin Elmer Ensdb Hsapiens
Source: nature.com

Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis

DNA double-strand breaks (DSBs) are deleterious lesions that challenge genome integrity. To mitigate this threat, human cells rely on the activity of multiple DNA repair machineries that are tightly regulated throughout the cell cycle1. In interphase, DSBs are mainly repaired by non-homologous end joining and homologous recombination2. However, these pathways are completely inhibited in mitosis3–5, leaving the fate of mitotic DSBs unknown. Here we show that DNA polymerase theta6 (Polθ...
United States Hela Gibco Biotinylated Pol Orbitrap Exploris Lipofectamine Rnaimax Thermofisher Jn Mark Glover
Source: nature.com

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A spatially resolved timeline of the human maternal–fetal interface

Beginning in the first trimester, fetally derived extravillous trophoblasts (EVTs) invade the uterus and remodel its spiral arteries, transforming them into large, dilated blood vessels. Several mechanisms have been proposed to explain how EVTs coordinate with the maternal decidua to promote a tissue microenvironment conducive to spiral artery remodelling (SAR)1–3. However, it remains a matter of debate regarding which immune and stromal cells participate in these interactions and how this...
Leica Biosystems Dako Agilent Nanostring Geomx Flowsom Bioconductor Flow Perivascular Evts Electron Microscopy Sciences
Source: nature.com

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