Zeiss Axioobserver News Today

This article outlines the role of molecular interactions in cell differentiation and cancer invasion.

P2RY8 is a G protein–coupled receptor (GPCR) that is involved in restraining germinal center (GC) B cell migration and growth. It is unclear how the ligand of P2RY8, S -geranylgeranyl-l-glutathione (GGG), is involved in these processes. Using gain-of-function mouse models and genetically modified human T cells, Gallman et al. showed that expression of gamma-glutamyltransferase-5 (Ggt5) on stromal cells and ATP-binding cassette subfamily C member 1 (Abcc1) on hematopoietic cells was involved in...