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Study reveals how DNA segments function in cells A new study co-authored by University of Colorado Cancer Center researcher Srinivas Ramachandran, PhD, shows how DNA segments known as enhancers function in cells. The paper published last month in Molecular Cell highlighted the work from Ramachandran, along with Satyanarayan Rao, both part of the Department of Biochemistry and Molecular Genetics at the CU School of Medicine, and Kami Ahmad from the Fred Hutchinson Cancer Research Center. Enhancers are DNA sequences that drive cell-type-specific gene expression, developmental transitions, and cellular responses to external stimuli. They typically have multiple binding sites for transcription factors, which are proteins that help turn specific genes on or off by binding to nearby DNA.

United statesKami ahmadSatyanarayan raoSrinivas ramachandranEmily hendersonCu school of medicineSchool of medicineUniversity of coloradoUniversity of colorado cancer centerDepartment of biochemistryFred hutchinson cancer research centerColorado cancer centerMolecular cellMolecular geneticsFred hutchinson cancer researchTranscription factors