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A small molecule inhibitor shows promise to reduce the growth of uveal melanoma Uveal melanoma, or UM, is a rare and deadly cancer of the eye, and the mortality rate has remained unimproved for 40 years. Half of the melanomas spread to other organs of the body, causing death in less than a year, so new treatments to preserve vision and prevent death are an urgent need. Now a preclinical study by researchers at the University of Alabama at Birmingham and Emory University, Atlanta, offers hope a small molecule inhibitor has been identified that dampens the potent drivers of this tumor. In mouse models, the inhibitor, KCN1, strongly limited primary disease in the eye and metastatic tumor dissemination to the liver, and animals survived longer, without overt side effects.

Hans grossniklausErwin van meirVan meirEmily hendersonEmory universityUniversity of alabama at birminghamஅர்‌விந் வேன் மீர்வேன் மீர்எமிலி ஹென்டர்சன்உணர்ச்சி பல்கலைக்கழகம்பல்கலைக்கழகம் ஆஃப் அலபாமா இல் பர்மிங்காம்