Most analyses of the antibody responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have focused on antibodies cloned from memory B cells. This approach has led researchers to conclude that neutralizing antibodies (nAbs) primarily target the receptor-binding domain (RBD) of the virus s spike protein. Voss et al. took a different approach, using proteomic deconvolution of the serum immunoglobulin G antibody repertoire from four COVID-19 convalescent patients. They found that the nAb response was largely directed against epitopes such as the N-terminal domain (NTD), which lie outside the RBD. Several of these nAbs were shared among donors and targeted an NTD epitope that is frequently mutated by variants of concern.
Science , abg5268, this issue p. [1108][1]
The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infecti
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IMAGE: This is a disguising machinery used by SARS-CoV-2, and the small green dot is a magnesium ion. view more
Credit: Yogesh Gupta, PhD, The University of Texas Health Science Center at San Antonio
SAN ANTONIO (June 2, 2021) Scientists from The University of Texas Health Science Center at San Antonio have discovered a mechanism by which SARS-CoV-2 exploits changes in metal ion concentrations to disguise itself in the body. Varying concentrations of metal ions positively charged atoms such as magnesium, manganese and calcium are observed in hospitalized COVID-19 patients. This is a newly described metal-dependent mechanism by which these ions help the virus to evade immune surveillance, said Yogesh Gupta, PhD, senior author of the research published June 2 in the journal
Perimeter Medical Imaging AI, Inc. a medical technology company driven to transform cancer surgery with ultra-high-resolution, real-time, advanced imaging tools to address high unmet medical needs, today reported financial results for its first quarter ended March 31, 2021 and provided a corporate update. Jeremy Sobotta, Perimeter’s Chief Executive Officer stated, “Supported by a strong balance sheet and a .
Meet a Texas Plant Hunter Who’s Combing Forests and Fields to Save Rare Flowers
Conservationist Adam Black roams the state looking for endangered flora, which he shares with researchers around the world.
June 1, 2021
Adam Black checks a small and precariously located colony of Oklahoma grass pinks he has marked with stakes.
Molly Glentzer
Adam Black parked his black Tundra beside State Highway 105 outside Brenham one morning in mid-April and trudged into an unruly-looking tangle of green stuff wedged between the asphalt and a scrubby tree line. Not far down the road, pastures were carpeted with
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/PRNewswire/ Hummingbird Bioscience, an innovative clinical-stage biotech company focused on developing precision therapies against hard-to-drug targets.