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Brain organoids ready for real-time observation
Cheap, multi-well device for brain development research.
A 3D-printed microfluidic bioreactor for organ-on-chip cell culture. Credit: Ikram Khan
A group of researchers has grown small, self-organising blobs of brain tissue in multi-welled dishes to observe in real time.
The team, from the Massachusetts Institute of Technology and the Indian Institute of Technology, created a way to cheaply feed brain organoids – small bits of tissue that function in an organ-like way – and keep them alive for observation.
This has previously been made difficult by the cost of equipment and the need for constant maintenance and fluids to keep the organoids alive. In this case, a nutrient medium was delivered through small tubes connected to a tiny platform that contained the tissue, a technique called microfluidics.