Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced new interim data from two studies of Evrysdi® (risdiplam); JEWELFISH and RAINBOWFISH. Data from JEWELFISH, an ongoing open-label study primarily evaluating the safety of Evrysdi in people aged 1 to 60 years who have been previously treated with another .
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Infant gut microbiota associated with fine motor skills The microbial landscape of a child s gut may impact their fine motor skills, representing a potential opportunity for probiotic interventions relevant to treatment for motor disorders, according to a new study.
The assembly of the gut microbiota starts from birth, characterised by a rapid rate of colonisation and expansion of gut bacteria dominated by
Actinobacteria and
Firmicutes and
Bacteroidetes.
Experiments in animal models have shown that this process is physiologically connected with the synaptogenesis in the cerebral cortex. Seminal studies in germ-free mice emphasised that early colonisation with a complete specific-pathogen-free microbiota ameliorated brain development and behavioural abnormalities. Cross-sectional clinical studies have also associated altered microbial composition with the pathophysiology of Alzheimer’s disease, autism spectrum disorder, mul