December 11, 2020
A new analysis of the ISCHEMIA trial reveals its results are highly contingent on how myocardial infarction is defined, with investigators reporting a significant treatment difference between the invasive and conservative strategies when counting MIs using the more-sensitive biomarker: cardiac troponin (cTn).
When investigators analyzed events based on the secondary MI definition, which assessed PCI- and CABG-related infarctions using cTn levels as opposed to CK-MB, the conservative strategy of guideline-directed medical therapy was associated with a significantly lower risk of the study’s primary endpoint, a composite of cardiovascular death, MI, hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest, and a lower risk of cardiovascular death or MI, which was a secondary endpoint.
10 Things You Don’t Know About Rheumatoid Arthritis
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If you or someone you love has rheumatoid arthritis (RA) there’s probably a lot you already know about the disease, like the fact that it’s a chronic illness that causes joint inflammation and pain, or that it affects three to four times as many women as men. But RA is still pretty mysterious the exact cause is unknown, for instance, as is why it strikes more women (though theories point to hormonal and immune system differences) and so researchers are busy sharing new insights on the regular. Here are 10 surprising facts and promising theories you should know about RA.
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