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Physical frailty syndrome: a cacophony of multisystem dysfunction

In the inaugural issue of the journal Nature Aging a research team led by aging expert Linda P. Fried, MD, MPH, dean of Columbia University Mailman School of Public Health, synthesizes converging evidence that the aging-related pathophysiology underpinning the clinical presentation of phenotypic frailty (termed as physical frailty here) is a state of lower functioning due to severe dysregulation of the complex dynamics in our bodies that maintains health and resilience. When severity passes a threshold, the clinical syndrome and its phenotype are diagnosable. This paper summarizes the evidence meeting criteria for physical frailty as a product of complex system dysregulation. This clinical syndrome is distinct from the cumulative-deficit-based frailty index of multimorbiditys. The paper is published online here.

New COVID-19 variant sparks calls for restrictions

SHARE: New York has entered a troubling new phase of the coronavirus pandemic: the state has confirmed four cases of a more contagious strain currently wreaking havoc in Britain. While much remains unknown about the new variant, public health experts said now is the time to take proactive steps to prevent worse-case scenarios. And they say that officials need to begin seriously considering the reintroduction of restrictions, like ending indoor dining statewide, to slow the spread.  New York state’s rate of positive coronavirus tests has been steadily increasing since the beginning of November. In the last month alone, the seven-day rolling average of positive cases has increased over 2% statewide, hitting nearly 8% recently. Various regions of the state have even higher rates of positive cases, as well as spikes in hospitalizations. Despite this, Gov. Andrew Cuomo has not announced any new microcluster zones, or updates to existing zones, since December 14, according to the webs

Early warning system fills in gaps in infectious disease surveillance

 E-Mail Researchers at Columbia University Mailman School of Public Health developed an infectious disease early warning system that includes areas lacking health clinics participating in infectious disease surveillance. The approach compensates for existing gaps by optimally assigning surveillance sites that support better observation and prediction of the spread of an outbreak, including to areas remaining without surveillance. Details are published in the journal Nature Communications. The research team, including Jeffrey Shaman and Sen Pei, have been at the forefront of forecasting and analyzing the spread of COVID-19. Their highly cited paper in the journal Science Advances estimated the number of lives saved had physical distancing and other measures taken effect one week earlier. They have also led the development of methods to forecast other infectious diseases, including seasonal influenza.

Are cities a safe place to live during a pandemic?

Christina Caron, The New York Times Published: 09 Jan 2021 03:00 PM BdST Updated: 09 Jan 2021 03:16 PM BdST A man checks his mobile phone as he sits in an alley inside Jerusalem s Old city as Israel tightens a national lockdown in a bid to curb a sharp rise in new coronavirus disease (COVID-19) infections, in Jerusalem Jan 8, 2021. REUTERS/FILE In the spring, as thousands of people were sickened by the coronavirus, the bodies began to pile up in one of the country’s densest urban centres: New York City. ); } News headlines rolled like a steady drumbeat of doom. The region became known as the epicentre of the pandemic. Economists predicted that the city’s recovery would take years. Some New Yorkers started moving out, “fleeing” to the suburbs.

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