By Nancy Lapid
April 19 (Reuters) - The following is a roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.
Physical inactivity tied to higher COVID-19 risks
Patients with COVID-19 who have been consistently physically inactive have a significantly higher risk of severe outcomes than patients who were getting at least some exercise or regularly met physical activity guidelines prior to the illness, researchers found. Among the 48,440 patients in their study, 14.4% were consistently inactive in the two years before their COVID-19 diagnosis, 79.1% had some activity, and 6.4% consistently met recommended physical activity guidelines of at least 150 minutes per week. Compared with those who consistently met activity guidelines, people who were consistently inactive were more than twice as likely to be hospitalized and to die from the virus, according to a report in the Briti
Physical inactivity tied to higher COVID-19 risk
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IMAGE: Dr. Marassi is director and professor in the Cell and Molecular Biology of Cancer Program at Sanford Burnham Prebys. view more
Credit: Sanford Burnham Prebys
LA JOLLA, CALIF. - April 20, 2021 Scientists at Sanford Burnham Prebys have identified, at an atomic level, how a part of a protein called PLEKHA7 interacts with a cell s membrane to regulate important intercellular communications. The research, published in the journal
Structure, points to hotspots within PLEKHA7 as targets for drugs. These targets could be key in designing treatments for advanced colon, breast and ovarian cancers.
The region, or domain, in PLEKHA7 that the researchers examined, pleckstrin homology (PH), is commonly found in proteins that regulate the movement of cells as well as other important cellular activities. If the interaction between the PH domain and the lipids that comprise cell membranes is disrupted, diseases such as cancer can occur.