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Riding the wave to memory-forming genetics

 E-Mail IMAGE: Above illustration shows a neuron (green) ensheathed by an oligodendrocyte (purple) with activated genetic material (DNA) in each cell s nucleus. Differences in each cell type s active DNA may underlie human. view more  Credit: Melissa Logies DALLAS - March 10, 2021 - UT Southwestern scientists have identified key genes involved in brain waves that are pivotal for encoding memories. The findings, published online this week in Nature Neuroscience, could eventually be used to develop novel therapies for people with memory loss disorders such as Alzheimer s disease and other forms of dementia. Making a memory involves groups of brain cells firing cooperatively at various frequencies, a phenomenon known as neural oscillations. However, explain study leaders Bradley C. Lega, M.D., associate professor of neurological surgery, neurology, and psychiatry, and Genevieve Konopka, Ph.D., associate professor of neuroscience, the genetic basis of this process is

Tea compound could lead to drugs that lower blood pressure

Compounds in both green and black tea relax blood vessels by activating ion channel proteins in the blood vessel wall, according to a new study. The discovery helps explain tea’s antihypertensive properties and could lead to the design of new blood pressure-lowering medications. The findings, published in Cellular Physiology and Biochemistry, reveal that two catechin-type flavonoid compounds (epicatechin gallate and epigallocatechin-3-gallate) in tea, each activate a specific type of ion channel protein named KCNQ5, which allows potassium ions to diffuse out of cells to reduce cellular excitability. As KCNQ5 is found in the smooth muscle that lines blood vessels, its activation by tea catechins was also predicted to relax blood vessels a prediction that colleagues at the University of Copenhagen confirmed.

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