Researchers explore early stages of ribosome formation to identify new targets for antibiotics
Ribosome formation is viewed as a promising potential target for new antibacterial agents. Researchers from Charité - Universitätsmedizin Berlin have gained new insights into this multifaceted process.
The formation of ribosomal components involves multiple helper proteins which, much like instruments in an orchestra, interact in a coordinated way. One of these helper proteins - protein ObgE - acts as the conductor, guiding the entire process. The research, which produced the first-ever image-based reconstruction of this process, has been published in
Molecular Cell.
Ribosomes are an essential component of all living cells. Frequently referred to as molecular protein factories , they translate genetic information into chains of linked-up amino acids which are otherwise known as proteins.
Tue, 03/02/2021
LAWRENCE – Students from each of the Kansas Board of Regents four-year public universities will share work during Kansas’ Undergraduate Research Days. The 2021 event will take place online March 2-4.
Ten University of Kansas students will share their work during the free event, which is hosted this year by Fort Hays State University.
“This event is a chance for our students to highlight the undergraduate research opportunities they have had as a result of their studies at the University of Kansas, as well as how this work enhances their own education while also improving the lives of Kansans. Although it is sad that we cannot meet in the Capitol, this virtual event should make it easier for more people to see the wonderful work being done by undergraduate students at KU and across the state,” said Alison Olcott, director of the Center for Undergraduate Research.
Commonly used sweeteners may promote antibiotic resistance
Researchers in Australia have conducted a study showing that commonly used nonnutritive sweeteners can promote the spread of antibiotic-resistant genes in the intestine.
The study found that the sweeteners saccharine, sucralose, aspartame, and acesulfame potassium all promoted horizontal transfer of the genes between bacteria in both environmental and clinical settings.
The sweeteners accelerated the exchange of antibiotic resistance genes (ARGs) via a process called conjugation. The genes are transferred from donor to recipient bacteria, which may then go on to develop multidrug resistance, says Zhigang Yu and colleagues from The University of Queensland in St. Lucia, Brisbane.
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European Medicines Agency Accepts Pfizer’s Marketing Authorization Application for Its Investigational 20-valent Pneumococcal Conjugate Vaccine for Adults 18 Years
If approved, the vaccine would help protect adults against 20 serotypes responsible for the majority of invasive pneumococcal disease and pneumonia
NEW YORK–(BUSINESS WIRE)– Pfizer Inc. (NYSE:PFE) today announced that the European Medicines Agency (EMA) accepted for review the Marketing Authorization Application (MAA) for its 20-valent pneumococcal conjugate vaccine (20vPnC) candidate, as submitted for the prevention of invasive disease and pneumonia caused by Streptococcus pneumoniae serotypes in the vaccine in adults ages 18 years and older. With the MAA acceptance, the formal review process by the EMA’s Committee for Medicinal Products for Human Use (CHMP) begins.