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A decade on from plain packaging, what is the result?

A decade on from plain packaging, what is the result? We’re sorry, this service is currently unavailable. Please try again later. Dismiss Normal text size Advertisement Cigarettes today are sold in drab olive-brown boxes, replete with yellow warning labels that shout “SMOKING KILLS” next to ugly photographs of gangrenous and rotting toes. There’s a whole generation of younger people who haven’t seen them sold any other way in Australia. Australia was the first country to introduce plain packaging rules. But more than a decade ago, plain packaging was far from reality as tobacco companies and libertarians fought against plans by the Rudd and Gillard governments to introduce it, alongside a hike in tobacco excise, aimed at reducing the number of smokers.

Fundamental mechanism discovered that fine-tunes gene expression & is disrupted in cancer

Credit: The Wistar Institute PHILADELPHIA and MELBOURNE, Australia (May. 17, 2021) A team of scientists from The Wistar Institute in Philadelphia and the Peter MacCallum Cancer Center in Melbourne, Australia, discovered a new checkpoint mechanism that fine-tunes gene transcription. As reported in a study published in Cell, a component of the Integrator protein complex tethers the protein phosphatase 2A (PP2A) to the site of transcription allowing it to stop the activity of the RNA polymerase II enzyme (RNAPII). Disruption of this mechanism leads to unrestricted gene transcription and is implicated in cancer. The study points to new viable opportunities for therapeutic intervention demonstrating the anti-cancer effect of a new combination treatment in preclinical models of solid and hematopoietic malignancies.

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