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How to have a safer, happy holiday: Lower-risk ways to find joy

(Rose Wong for NPR) It’s supposed to be the happiest time of the year, but this year it doesn’t really feel like it. With many of us hunkered down at home, some having lost jobs, others having lost friends and family members to COVID-19 or other illnesses, it’s tempting to give this holiday season a miss. But it’s important to find joy and meaning in the midst of this dark winter and carrying on with favorite holiday traditions can help. NPR checked in with medical researchers to figure out how risky our favorite customs are, and highlight ways we can all celebrate more safely.

SUO 2020: Results from the PROfound Study, A New Second Line Therapy for mCRPC

SUO 2020: Results from the PROfound Study, A New Second Line Therapy for mCRPC (UroToday.com) In the second Prostate Cancer session at this year’s Society of Urologic Oncology virtual annual meeting, Dr. Maha Hussain discussed the role of poly ADP ribose polymerase (PARP) inhibitors, particularly olaparib, in metastatic castration-resistant prostate cancer. Dr. Hussain began by reviewing the rationale for targeting PARP-1 in advanced prostate cancer given its implicated role in many aspects of prostate cancer including its role in mediating DNA repair response to alkylating agents, in cellular survival in BRCA deficient cells, and in androgen-receptor mediated prostate cancer cellular proliferation. Further, the Stand Up To Cancer (SU2C) project analysis demonstrated that more than 20% of patients with mCRPC harbor DNA repair pathway aberrations including BRCA2, BRCA1, ATM and many others of which 8-10% are pathogenic germline findings.

What s a heater gonna do when it s 30 degrees : Restaurants face bleak winter in COVID-19

What s a heater gonna do when it s 30 degrees : Restaurants face bleak winter during COVID-19 Ryan W. Miller, Grace Hauck and Kelly Tyko, USA TODAY Indoor dining banned in NYC to limit virus spread Replay Video UP NEXT NEW YORK – Billy Cole said the restaurant has lost tens of thousands of dollars since the start of the pandemic, if not $100,000.  Workers have been furloughed and salaries cut at Little Dokebi, a Korean restaurant in Brooklyn s Greenpoint neighborhood. Despite the losses, it s been one of the lucky ones because it s on a corner with plenty of outdoor dining space, said Cole, the general manager.

What s a heater gonna do when it s 30 degrees : Restaurants face bleak winter during COVID-19

What s a heater gonna do when it s 30 degrees : Restaurants face bleak winter during COVID-19 Ryan W. Miller, Grace Hauck and Kelly Tyko, USA TODAY Indoor dining banned in NYC to limit virus spread Replay Video UP NEXT NEW YORK – Billy Cole said the restaurant has lost tens of thousands of dollars since the start of the pandemic, if not $100,000.  Workers have been furloughed and salaries cut at Little Dokebi, a Korean restaurant in Brooklyn s Greenpoint neighborhood. Despite the losses, it s been one of the lucky ones because it s on a corner with plenty of outdoor dining space, said Cole, the general manager.

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