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Credit: NYU Abu Dhabi
A revolutionary technology developed within the Trabolsi Research Group at NYU Abu Dhabi (NYUAD) could dramatically improve the well-being of diabetic patients through a simple and straightforward way: an insulin oral delivery system that could replace traditional subcutaneous injections without the side effects caused by frequent injection.
Using prepared layers of nanosheets with insulin loaded in between layers to protect it, researchers developed gastro-resistant imine-linked-covalent organic framework nanoparticles (nCOFs) that exhibited insulin protection in the stomach as well in diabetic test subjects whose sugar levels completely returned to normal within two hours after swallowing the nanoparticles. Led by NYUAD s Research Scientist Farah Benyettou and Program Head of Chemistry Ali Trabolsi, the findings were published today in
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IMAGE: A new study using mouse models of neurodevelopmental disorders identifies alterations in energy metabolism that are sex-specific and distinct between models. These findings point to novel peripheral anomalies and force. view more
Credit: Illustration by Baptiste Lacoste. Created with BioRender.com
Mouse models of neurodevelopmental disorders possess unique, sex-specific metabolic dysfunctions, according to a new study in
eNeuro. Understanding the unique metabolic effects of each disorder in both animal models and humans may lead to more personalized treatments and diagnostic methods.
Any disorder affecting the brain also impacts the body. People with neurodevelopmental disorders including Down syndrome and autism spectrum disorders are at increased risk for developing diabetes, obesity, and hypertension. Yet the impact of these three disorders on metabolism has not been studied.
A new Viewpoint article argues that today s health and equity challenges call for the US to shift from food insecurity to nutrition insecurity in order to catalyze appropriate focus and policies on access not just to food but to healthy, nourishing food.
A series of studies led by researchers from Hong Kong Baptist University (HKBU) have revealed that hyocholic acid and its derivatives (collectively known as HCAs), a component of bile acids that facilitate fat digestion, are a promising risk indicator of type 2 diabetes. The strong efficacy of HCAs in regulating blood glucose levels and protecting against diabetes has also been uncovered. The findings open a window for the development of HCA-based predictive markers as well as anti-diabetic drugs.
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IMAGE: Dr. Andrew Gewirtz, a professor in the Institute for Biomedical Sciences at Georgia State University view more
Credit: Georgia State University
ATLANTA Dr. Andrew Gewirtz, a professor in the Institute for Biomedical Sciences at Georgia State University, has received a four-year federal grant just over $2 million to study how inflammation and altered gut microbiota, the microorganisms living in the intestine, influence the development of a group of diseases referred to as metabolic syndrome.
Between 50 to 80 million Americans suffer from metabolic syndrome, an epidemic of interrelated obesity-associated disorders including insulin resistance, hyperglycemia (high blood sugar), hyperlipidemia (high cholesterol) and hepatic steatosis (fatty liver). Many of these individuals will develop serious, costly diseases such as type 2 diabetes, cardiovascular disease and liver failure.