Mouse models of neurodevelopmental disorders display metabolic dysfunction

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IMAGE: A new study using mouse models of neurodevelopmental disorders identifies alterations in energy metabolism that are sex-specific and distinct between models. These findings point to novel peripheral anomalies and force...
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Credit: Illustration by Baptiste Lacoste. Created with BioRender.com
Mouse models of neurodevelopmental disorders possess unique, sex-specific metabolic dysfunctions, according to a new study in
eNeuro. Understanding the unique metabolic effects of each disorder in both animal models and humans may lead to more personalized treatments and diagnostic methods.
Any disorder affecting the brain also impacts the body. People with neurodevelopmental disorders -- including Down syndrome and autism spectrum disorders -- are at increased risk for developing diabetes, obesity, and hypertension. Yet the impact of these three disorders on metabolism has not been studied.

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