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In mice, antibody removes amyloid, improves vessel function without raising risk of brain bleeds
Amyloid deposits (blue) in mouse brain tissue and blood vessels are reduced after treatment with an antibody that targets the protein APOE (right), a minor component of amyloid deposits, compared to a placebo antibody (left). Amyloid deposits in the brain increase the risk of dementia and strokes. Researchers at Washington University School of Medicine in St. Louis have identified an antibody that clears amyloid deposits from the brain without raising the risk of brain bleeds. (Image: Monica Xiong)
February 17, 2021 SHARE
As people age, a normal brain protein known as amyloid beta often starts to collect into harmful amyloid plaques in the brain. Such plaques can be the first step on the path to Alzheimer’s dementia. When they form around blood vessels in the brain, a condition known as cerebral amyloid angiopathy, the plaques also raise the risk of strokes.
February 17, 2021
by Jeanna Lucci-Canapari
A multi-institution symposium led by Yale School of Medicine treated more than 1,900 online participants from across the country to a showcase of research from a diverse group of talented postdoctoral researchers, with the goal of propelling their promising careers in scientific discovery. The Intersections Science Fellows Symposium was held through Zoom sessions and webinars from January 6 through 8, and was hosted by a coalition formed by Yale and 25 other national research institutions.
The symposium featured the research contributions from 26 junior scientists, who were chosen to present their work as 2021 Intersection Science Fellows. Selected from a pool of more than 400 applicants, the fellows largely represented communities that have been historically unrepresented in the field of medical research, including those from ethnic and racial minorities, those with disabilities, those from low socioeconomic backgrounds, women, or those
For bleeding patients, can cold storage of platelets improve blood clotting?
$26 million in funding to help determine whether cold platelets can reduce blood loss more effectively than those stored at room temperature
The image illustrates platelets, which are essential for normal blood clotting in the body. Platelets are the focus of a large, multicenter study led by researchers at Washington University School of Medicine in St. Louis and the University of Minnesota Medical School in Minneapolis. The researchers want to know whether maintaining platelets in cold storage is as effective in reducing blood loss as platelets stored at room temperature and whether the shelf life of cold platelets can be safely extended to 21 days. (Image: Getty Images)
Scientists Generate Detailed Map of Glioblastoma Genes, Proteins, Infiltrating Cells and Signaling
February 12, 2021
Pictured are MRI scans of eight patients with glioblastoma, an aggressive brain tumor. A new study led by Washington University School of Medicine in St. Louis has mapped out detailed molecular and genetic schematics of these tumors, opening the door to potential improved therapies. [Albert H. Kim]
A study led by researchers at Washington University School of Medicine in St. Louis, Pacific Northwest National Laboratory, Case Western Reserve University, and the National Cancer Institute (NCI), has revealed a detailed map of the genes, proteins, infiltrating cells and signaling pathways that play key roles in driving glioblastoma (GBM).