Ocuphire Pharma Initiates LYNX-1 Phase 3 Study Investigating Nyxol in Night Vision Disturbances
January 05, 2021 07:00 ET | Source: Ocuphire Pharma Ocuphire Pharma
Nyxol is in Late Stage Clinical Development for A New Ophthalmic Indication
Top Line Data from LYNX-1 Expected 3Q2021
FARMINGTON HILLS, Mich., Jan. 05, 2021 (GLOBE NEWSWIRE) Ocuphire Pharma, Inc. (Nasdaq: OCUP), a clinical-stage ophthalmic biopharmaceutical company focused on developing and commercializing therapies for the treatment of several eye disorders, announced the initiation of patient recruitment and screening in late December for its LYNX-1 Phase 3 registration study evaluating the safety and efficacy of Nyxol
® in night vision disturbances (NVD) at multiple sites in the US.
Study: Brain malformation traceable to genetic roots ANI | Updated: Jan 02, 2021 21:41 IST
Washington [US], January 2: A recent study has revealed that common brain malfunctions can be traced to their genetic roots. This discovery could help in aiding early screening and shed light on how Chiari malformation arises.
According to a study published in American Journal of Human Genetics about one in 100 children has a common brain disorder called Chiari 1 malformation, but most of the time such children grow up normally and no one suspects a problem. But in about one in 10 of those children, the condition causes headaches, neck pain, hearing, vision and balance disturbances, or other neurological symptoms.
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A common brain disorder called Chiari 1 malformation can result from variations in two genes involved in brain development, research finds.
The study also reveals that children with unusually large heads are four times more likely to be diagnosed with Chiari 1 malformation than their peers with normal head circumference.
The condition occurs when the lowest parts of the brain are found below the base of the skull.
About one in 100 children has Chiari 1 malformation, but most of the time such children grow up normally and no one suspects a problem. But in about one in 10 of those children, the condition causes headaches, neck pain, hearing, vision and balance disturbances, or other neurological symptoms.
At 15:03 on an otherwise-normal afternoon in 2014, an 85-year-old male developed a sudden onset of right-sided weakness. Upon witnessing his symptoms, a family member called emergency medical services at 15:08. At 15:13 EMS arrived.
The crew’s initial exam demonstrated an alert and oriented 100-kg geriatric male with marked weakness of his right arm and leg. His past medical history included coronary artery disease, chronic obstructive pulmonary disease, deep vein thrombosis status post-IVC filter, hypertension, and chronic atrial fibrillation. As scene time progressed, the patient became progressively aphasic and altered, with a final Cincinnati Stroke Scale score of 2 for arm drift and slurred speech.