President elect. Joe biden is to announce his 1st cabinet appointments. And he brings in a former Obama Administration official is expected to be secretary of state. So this promising news this monday in the search for a Coronavirus Vaccine astra zeneca has said that late stage testing of its covert 19 treatment shows it can be up to 90 percent effective without any serious side effects. The company has been developing the vaccine with oxford university. Importantly says it can be stored at frigid temperatures, making it easier to distribute the u. K. Health secretary, matt hancocks, is 100000000 doses are on order and it could start to be rolled out next month. John, how in london to talk us through that when it all sounds pretty good. Just one about the word and it can be up to 90 percent effective if you got more data. Yeah, its important that astra zeneca, the British Pharmaceutical Company that partnered with the university of oxford said this morning when they announced these results that there was a discrepancy between different possible dosing regimes. Producing results between the early sixtys percent range up to 90 percent said they in fact asked to have gone with an average efficacies rate of 70 percent, which is less, it has to be said than the pfizer and modernity. Vaccines vying for regulator approval in the United States. Nevertheless, a hugely important breakthrough this, according to astra zeneca, 1st of all, no serious side effects, as you said there. Secondly, importantly, all those people in the large scale trials that have been taking place in this country in brazil and south africa who do still contract the virus with this vaccine. They do so only with mild symptoms. So it seems to eliminate altogether serious instances of disease disease thats important. Its also shown to be far more practical. It seems than those other vaccines in the sense that it is much, much cheaper in terms of scaling up mass producing. Also, as you mentioned, it can be stored at fridge temperatures that lead to an 8 degrees celsius to keep it fresh, to keep it usable, as opposed to the far subzero temperatures down to 70 minus 70 percent. 70 degrees. Rather that the fires of vaccine needs to be sought out in developing parts of the world. Thats just impossible, in many of the hottest and poorest countries. So this vaccine, the pfizer, the astra zeneca vaccine, much more practical in terms of global distribution, particular to poor parts of the world. Theyre talking about producing up to 3000000000 doses in 2021 alone. With the 1st rollout of initial doses to the most vulnerable in this country. Possibly by the end of december. Thank you. John howell, leave you there because ive also got mohammed mania to talk to now for all of us, from Lancaster University in the u. K. , your initial thoughts 1st of all about how effective this could be. Bearing in mind what jonah said there about the average success rate. Yes, absolutely. Thank you very much for having me on the show. I think this is really important to understand because they used to defend those regime in phase 3 trial. And one of them was 90 percent effective. Another one was 60 percent effective and then they took the average of that as a 70 percent, which isnt really practical because you, you can only use one dosage of a game into the beijing, you know, into the, into the people. So i that it is 90 percent or 60 percent. If it is 90 percent, depending on the building, a game is incredible news. But if it is 60 percent, then it is not really that impressive because of course, with all of the possibilities of distribution, storage cost a lot of wanted use. But when it comes to safety and efficacy, it was intended to compare it. Ok, safety is something i do want to talk about. Part of me feels we should be really impressed with the fact that 3 companies now have managed to come up with something inside 10 months. But its also something that would usually take many more years to come up with. Does that raise safety concerns . It well is it does to some extent because as you said, that we have a normal procedure for any vaccine for approval. And the trial is on 15 years and now everything is free as 1000000 to one year. But under top of it, i think one of the concerns that i as a disservice should have is that im on it based maxines are not really something that has been tried in human on that scale before. So certainly this is a, i mean they do hold clearly has been launched for 2 months. So what were talking about the safety and efficacy is a bit in those 2 months. What happened beyond that is something is questionable, sort em out in the midst of axing because of new technology. But when it comes to us for that in the white house, these have been used in the field before. For example, just for the ball. A vaccine has been on today, i added a virus and i dont know why this is, have been used for many other diseases, including speak about us as whats so we have a crack back order of safety and efficacy of our own, the added alliances. So therefore i did, it is more crosswords, it will have something to take a knowledge of that has been tested before. Now, we were discussing amongst ourselves a little bit earlier here actually about how often you would need some sort of i mean a few, a flu jab, unsorry is often seen as a thing which you can get. Do you anticipate this is what the coronavirus or the covert 19 vaccine will be like as well . It . Yes, exactly. I mean, we dont really know exactly for a whole lot of the immunity were lost, but based on our experience, we have game sold for about persistence of the antibodies from the nature of the infected person is around 8 months to 9 months depending on hold. We look into from the beginning to date, to decline. We post here its, but actually the antibody response of that raised by the nature of infection is different than it is. It is by the vaccine. So when a vaccine entered into the body, there is a, for almost, i mean, for sponsors and the antibody teacher would be higher. The level of antibody would be higher than you get from the neutral source of infection. So i anticipate that at least this immunity induced by the vaccine will last at least 41 years, but certainly it would still be we, i want to share in moment because we know were headed next. You know, it is for all of us before. So having this show such a short time, it may be promising resurvey certainly very encouraging sign. Much of what we hear at the moment is not to be complacent. Yes, a vaccine is clearly coming, but obviously we still need to think about mosques, and we still need to keep up with our social distancing. Lets say we get to a point where a large proportion of people are vaccinated. Well, it still be wise then to still be thinking about masks and social distancing off to that. I mean, this is a 1000000 dollar question that nobody asked me before, but this is absolutely something we have to battle. And the thing is that all of the vaccines a lot in the front runner need to protect people from getting the severe form of the infection. For example, if somebody is that severe, dangerous, they might have severe, less severe consequences. But the thing that is important is that they will stop transmitting the infection. So this mean that the people who are vaccinated may have a less disease, but they still are shutting the virus. They are supporting the infection within the community. And to me or less at this moment, transmission has been the major problem than the protection because we have learned so much older disease. We know how to manage it. As you can sort example compare compared to the 1st debate. Now in the 2nd wave, we have 50 to 60 percent less mortality because we have managed thats the problem has been the virus in transmitting so much there for me that they impact has been very high. So until any vaccine data would block the transmission of the infection from one person to another person, we should not anticipate that this vaccine would be a minute magic bullet. And until we have to practice all the basic Public Health and simple spacing and avoiding him, dont play, says mohammed bin it, your information has been really, really valuable. And im also glad i could ask you a question. You hadnt been asked before. Many a from Lancaster University where i mean, thank you. Lets move on to other news. The israeli Prime MinisterBenjamin Netanyahu has made an unannounced visit to saudi arabia. To meet the crown Prince Mohammed bin salman, the head of Israeli Intelligence agency, mossad, and the u. S. Secretary state might. Pompei were also there was actually in israel just last week as well. It follows, a recent washington brokered normalization deals between israel and the u. A. E. , as well as more with kerry for said his reporting from ramallah in the occupied west bank today. Last time you and i spoke harry, it was the fact that this information and sort of leaked out but leaked out very quickly and now its becoming official. Oh yes, we dont have a perfectly official confirmation yet, but it, it is the kind of secret meeting that you have. If you dont really want to have a secret meeting, it seems the israelis, the saudis, and the u. S. Secretary of state all said to be in this future resort town of the arm on the, on the Saudi Arabian red sea coast late on sunday night. Now this 1st came to light from tracking of an airplane which has been leased by the Israeli Government for Benjamin Netanyahu. Zeus before it was seen making this route from tel aviv to staying there for about 5 hours. And then returning at a time when it was known that the pompei o. And the crown prince of saudi arabia, muhammad bin salman, were both there. Usually if there is a story that the Israeli Security establishment doesnt want to come out, there are Strong NationalSecurity Military censorship laws in israel, which gives you all sorts of strange wording in israeli media reporting about foreign sources, according to foreign reports and the like. There was none of that. This all came from domestic political israeli journalist. So theres obviously a real will to have this leak out and certainly no denial of it as far as the reaction coming from here. The palestinian leadership hasnt said anything on the record because again, theres been no official confirmation. But speaking to some senior officials, one of them said that if it were true, it would be heartbreaking. Another said that while they do point to the language used by the Saudi Foreign minister recently when he said there would be no normalization with israel before a palestinian state. He also said that there were no guarantees when the u. A. E. And israel signed their normalization deal. It was sort of again, confirmation of something we already knew was in it. Is that the same case with saudi arabia that actually there have been back channels for some time . Well, both yes and no, certainly we know that there have been all sorts of clandestine links that Benjamin Netanyahu has made it a key part of his more than 10 year administration. Now this time around to try to gain these sorts of alliances, especially with saudi arabia. And especially on the issue of iran, but the idea that an israeli Prime Minister would go to south to saudi arabia and have talks and do very little to try to conceal. That fact is certainly something thats very different and very deliberate, both on his part and indeed on the saudi and American Parts as well. Because presumably, all parties would have known that this would come out in due course. So it does suggest that there are continuing efforts by the trumpet, ministration, even in this last week to try to cement and make progress on the normalization situation that it has tried to promote in the region potentially also trying to box in a future by demonstration on such an issue as iran, and it could well have domestic political consequences as well. Netanyahu social media adviser tweeted out that benny gantz, the coalition partner, and erstwhile rival was playing politics while netanyahu was making peace. That was a reference to some ructions in the Coalition Government at the moment. The fact that didnt even inform his Coalition Partners about this beforehand again suggests that that coalition is heading towards dissolution pretty quickly. It seems and we may well have another round of elections on the cards. Harry forsett with all that news reporting from ramallah today. Thank you howard. I think a political analyst is now in the shower and he said, this really is all about the legacy of the trumpet ministration in its final weeks. Certainly its part of the race with time. I think everyone understands despite his trenches and its the Top Administration will come to an end january 20th. And i think the Top Administration is trying to cement its whatever legacy hes leaving behind in the middle east, especially in terms of the socalled deal of the century. That basically underlines the potential normalize issues between arab states and israel. Now, despite all the hoopla about bahrain or the u. A. E. , normalizing relations with israel, everyone understands that without saudi. This is all just an air hot air in the end of the day without riyadh coming into the fold. This will be iran where this will remain shaky and weak and i think its important for sticker to bumper you on the Top Administration to bring in that then the arrow and the comprehension order to see if there are ways by which to convince that that ambitious crown prince, that it is in the best interest of saudi arabia to normalize relations with israel. d before january 20th, in the news ahead, he was known as the bling bling president. But now Nicolas Sarkozy is facing corruption charges in court. And warnings of an environmental disaster look at the Impact Real Estate project could have on pakistans mandarins. However, once again, the weather doesnt say bad for china over the next couple of days. We have got some wet weather just pulling away from japan. No, there are some active weather systems, just easing over towards the eastern side of the country. But some places the snow up towards chicago for a time, but clear weather fresh weather coming back in as we go on through choose day celsius in seoul, some of the temperatures there for beijing central parts of china has been recently. But we will see somewhat of weather, just coming through as we go on into where the stay cold just sinks a little further south, which in the rain starts to push its way into the southern half of china. Still wanted to show as close to that eastern side of japan, not too bad. 14 celsius in tokyo then. Well for india, a very different story here. Some really wet weather down towards the southeastern corner, helping tropical system coming through here. That will feed some really nasty weather into tom will not be into southern parts of under protest as well as we go on into wednesday. Winds picking up some very, very heavy rain. It is likely to cause some flooding in the process. Further north, it is generated dry and fine westleys making their way in across northern parts of pakistan into the north of india. Hopefully here it will clear the air frank assessments, if American Public opinion is betrayed by social media platforms after november. What would be good . Because cautious and if you believe that there horowitz into our democracy, one obvious solution is to read from an informed opinion. Look at checkers, dont go anywhere. The protesters arent going anywhere, either. Its ability to get revolution. Indepth analysis of the days global headlines. Who is it thats really out there on the street inside story on aljazeera. With aljazeera. These are the top stories, astra zeneca and oxford university, say the late stage testing of their code 19 back scene shows it is up to 90 percent effective. The company says it can also be stored at frigid temperatures, making it easier to distribute. The israeli Prime MinisterBenjamin Netanyahu has made and unannounced visit to saudi arabia to meet crown Prince Mohammed bin salman, head of Israeli Intelligence agency, mossad. And the us sectors take might compare, were also things the leader of ethiopia has to grow. The region has dismissed a 72 hour deadline to surrender issued by the ethiopian government. This is according to reuters, which quotes the brits saying to people are ready to die, to defend the region. Prime minister hatoyama told it to Peoples Liberation front to lay down arms by wednesday or face a final assault on the city of mackellar. Local media is reporting the forces of in fact destroyed an airport in the town of oxen to slow the governments advance, malcolm web following developments for us from nairobi in neighboring kenya. Theyve refuted that demand for them to lay down arms. This certainly no sign of that and neither side have been talking to each other for months now. And that was part of the issues that led up to this conflict. The complete breakdown in the breakdown in communication, the total refusal of both sides to recognize the others legitimacy. Now for the 300000. 00 people that live in the town of me, kelly, if theres to be heavy fighting or a battle there, itll certainly be quite dangerous for them. Now the federal troops have insisted that theyre only targeting to gray and leadership in the to grain military and aligned militia, but certainly hundreds, possibly thousands of people have been killed in this conflict so far in fighting international rights. And certainly the movement of people show that people, disability living in the area certainly dont feel safe about 40000, people refugees have already crossed to neighboring to don prodemocracy activists. Joshua wang has pleaded guilty to Unlawful Assembly during last