Amyloid plaque mutation map opens new avenues for early dete

Amyloid plaque mutation map opens new avenues for early detection of Alzheimer's disease


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IMAGE: Mireia Seuma (left), first author of the study and researcher at IBEC next to Benedetta Bolognesi (right), one of the lead authors of the study and Junior Group Leader at...
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Credit: The Institute for Bioengineering of Catalonia, IBEC
A study published in the journal
eLife made all the possible mutations in the amyloid beta peptide and tested how they influence its aggregation into plaques, a pathological hallmark of Alzheimer's disease.
The comprehensive mutation map, which is the first of its kind, has the potential to help clinical geneticists predict whether the mutations found in amyloid beta can make an individual more prone to developing Alzheimer's disease later in life.

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Benedetta Bolognesi , Mireia Seuma , Ben Lehner , Research Professor , Centre For Genomic Regulation , Institute For Bioengineering Of Catalonia , Junior Group Leader , Genomic Regulation , Variant Effects , Biology , Cell Biology , Genetics , Molecular Biology , Neurobiology , Alzheimers Disease , Bioinformatics , ஆராய்ச்சி ப்ரொஃபெஸர் , நிறுவனம் க்கு உயிர் பொறியியல் ஆஃப் கட்டலோனியா , ஜூனியர் குழு தலைவர் , மாறுபாடு விளைவுகள் , உயிரியல் , செல் உயிரியல் , ஜெநெடிக்ஸ் , மூலக்கூறு உயிரியல் , நரம்பியல் , அல்சைமர் நோய் , உயிர் தகவலியல் ,

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