Originally scheduled to meet in Rome, Italy, the Aspen Global Congress on Scientific Thinking & Action took form as a virtual congress in March 2021. On this occasion, the Aspen Institute Science & Society Program (USA) and the Instituto Questão de Ciência (IQC, Question of Science Institute, Brazil), in partnership with the Aspen Institute Italia and EquiTech Futures, convened more than 100 scientists, scholars, journalists, and communicators from more than 50 countries around the world. Through presentations by leading experts, small-group breakout sessions, and all-group discussions, the congress focused on global themes that transcend geographical boundaries: science literacy, science popularization, vaccines, climate change, medicine, and food biotechnologies.