Good afternoon and welcome to the bbc news at one. A Ground Breaking vaccine for melanoma skin cancer is being trialled in the uk. The jab, which is personalised, uses the same technology as that in some covid vaccines. Early studies show that when used with another cancer drug it almost halved the risk of recurrence or death after three years. Melanoma is the most serious form of skin cancer and can spread to other areas of the body. The main cause of melanoma is Ultraviolet Light which comes from the sun and is used in sunbeds. Around 17,500 people are diagnosed with melanoma each year in the uk. Its the uks fifth most common cancer, but experts say 86 of these cases could be prevented by taking the right precautions. Heres our health correspondentjim reed. Could a jab like this change the way cancer is treated . Last month, steve young became the first person in the uk to be given this personalised vaccine, not to prevent the disease, but to try to stop a skin cancer returning. At least by being on a trial, im actively doing something that, you know, im having a fight, basically, im having a fight with whatever it was that gave me a melanoma. Last summer, steve had this tumour removed from his scalp. Those same cancer cells were flown to the United States and used to make the new experimental treatment. By priming, or preparing, his immune system, the hope is that steves own body can better find and attack any cancer cells left over after his surgery. The trials being run at this hospital in london and others are based on the same Technology Used in some covid jab called mrna, combined with a second treatment. Early Research Suggests it significantly reduced the risk of this specific skin cancer called melanoma returning three years after surgery. Researchers hope the same approach could work more widely. The real potential here, of course, is expanding this into other cancers because its not a technology that just works in one cancer. If it works in melanoma, it could work across a number of different cancers, lung cancer, bowel cancer, Kidney Cancer etc. So theres a potential here for a really transformative change in how we treat patients with cancer. For patients like steve, a musician from hertfordshire, the hope is this personalised approach will one day sit alongside proven treatments like radiotherapy and chemotherapy. Weeks on from his treatment, he is thinking about his future. Ifeel like i have this new lease of life and im actually really loving life at the moment, and ijust really hope that whats happening with the trial and the results they get are going to be good news and its going to go on to do amazing things. The uk arm of this global trial is taking place at this hospital and seven other sites across the country. But this is still very early stage research, with full results not expected before the end of the decade. Jim joins me now. So no full results for quite a while. How soon might patients benefit more widely . That while. How soon might patients benefit more widely . While. How soon might patients benefit more widely . That is the key cuestion. Benefit more widely . That is the key question the benefit more widely . That is the key question. The vaccine benefit more widely . That is the key question. The vaccine we benefit more widely . That is the key question. The vaccine we are benefit more widely . That is the key question. The vaccine we are talking | question. The vaccine we are talking about was developed by the Us Biotech Company moderna. You might remember that name from the covid jabs. Its big rival biontech, who developed the pfizerjab, is working on technology in the same area, trying to use mrna jabs to treat other diseases, notjust cancer. Im looking at a list of trials here hiv, malaria, shingles, influenza, even cystic fibrosis. These trials are going on at the moment. We shouldnt get too carried away, though. There is a Long Way To Go before anyone is receiving this regularly in the hospital or in pharmacy. Its one thing to develop these personalised vaccines for, say, cancerfor people in clinical trials, a few dozen people, quite another to scale this up so Tens Of Thousands of patients could receive these on the nhs. So its encouraging and exciting, but there is a Long Way To Go, a lot of science to do yet. Is a Long Way To Go, a lot of science to do yet. A key figure who handled many sub postmasters� complaints about the Horizon It System has been giving evidence for a second day. Angela van den bogerd was a senior figure at the post office for a number of years. Our correspondent, zoe conway, joins us from the inquiry in Central London. The inquiry this morning has really been dominated by the story of Martin Griffiths, a sub postmaster who took his own life in 2013. What they have been looking at is how the Senior Management at the post office behaved in the aftermath of his death. Martin griffiths, a sub postmaster in cheshire, for 18 years. The post office said he was responsible for Tens Of Thousands of pounds of missing money. His contract, terminated, left a broken man. I appreciate you wouldnt have received this letter at the time. Martin griffiths wrote to the post office in 2013, begging for help. The financial strain on myself and my family is devastating and continues on a daily basis. But his family says continues on a daily basis. But his family says the continues on a daily basis. But his family says the help continues on a daily basis. But his family says the help didnt continues on a daily basis. But his family says the help didnt come. L continues on a daily basis. But his i family says the help didnt come. He took his own life. fin family says the help didnt come. He took his own life. Took his own life. On the 11th of october 2013, took his own life. On the 11th of october 2013, his took his own life. On the 11th of october 2013, his life took his own life. On the 11th of october 2013, his Life Support L October 2013, his Life Support Machine was switched off and he passed away that day. Machine was switched off and he passed away that day. While Martin Griffiths was passed away that day. While Martin Griffiths was in passed away that day. While Martin Griffiths was in hospital, passed away that day. While Martin Griffiths was in hospital, at passed away that day. While Martin Griffiths was in hospital, at The Griffiths was in hospital, at the top of the post office, the Media Strategy was being prepared. Please can we line up strategy was being prepared. Please can we line up a strategy was being prepared. Please can we line up a specialist strategy was being prepared. Please can we line up a Specialist Media can we line up a Specialist Media lawyer in case we need urgent advice this evening . So the Immediate Reaction, you agree, was not is Martin Griffiths all right, what about his health . , was it . Hot Martin Griffiths all right, what about his health . , was it . Not at this oint about his health . , was it . Not at this point in about his health . , was it . Not at this point in this about his health . , was it . Not at this point in this email about his health . , was it . Not at this point in this email chain, about his health . , was it . Not at this point in this email chain, no. This point in this e mail chain, no. The Immediate Reaction was not what can we, the post office, due to help this mans family . . Can we, the post office, due to help this mans family . This mans family . , was it . Not at this mans family . , was it . Not at this point this mans family . , was it . Not at this point. What this mans family . , was it . Not at this point. What about this mans family . , was it . Not at this point. What about his this mans family . , was it . Not at this point. What about his wife this mans family . , was it . Not at this point. What about his wife and l this point. What about his wife and children . What this point. What about his wife and children . What about this point. What about his wife and children . What about his this point. What about his wife and children . What about his elderly i children . What about his elderly parents . What about his sister . Should we get somebody down to the hospital . That didnt happen, did it . Not getting somebody down to the hospital. The first thing was, lets get a media lawyer. Hospital. The first thing was, lets get a media lawyer. When i saw this, i didnt get a media lawyer. When i saw this, i didnt know get a media lawyer. When i saw this, i didnt know martin. Get a media lawyer. When i saw this, i didnt know martin. This get a media lawyer. When i saw this, i didnt know martin. This was get a media lawyer. When i saw this, i didnt know martin. This was my i didnt know martin. This was my first involvement in it and i was genuinely first involvement in it and i was genuinely concerned for the family. There genuinely concerned for the family. There didnt seem to be any end to it. A, ,�. , there didnt seem to be any end to it. Martin griffiths Widow Gina Soke to it. Martin griffiths widow gina spoke to bbc it. Martin griffiths widow gina spoke to bbc panorama it. Martin griffiths widow gina spoke to Bbc Panorama Two. It. Martin griffiths widow gina spoke to Bbc Panorama Two years ago. The worst thing for me was seeing my chiidren the worst thing for me was seeing my children having the worst thing for me was seeing my children having to the worst thing for me was seeing my children having to see the worst thing for me was seeing my children having to see their the worst thing for me was seeing my children having to see their dad children having to see their dad die. Children having to see their dad die and children having to see their dad die and it children having to see their dad die. And it was children having to see their dad die. And it was purely children having to see their dad die. And it was purely down children having to see their dad die. And it was purely down toi children having to see their dad i die. And it was purely down to the post office die. And it was purely down to the post office. The die. And it was purely down to the post office post office. The post office gave Gina Griffiths post office. The post office gave Gina Griffiths £140,000 post office. The post office gave Gina Griffiths £140,000 payoff, | post office. The post office gave i Gina Griffiths £140,000 payoff, but Gina Griffiths £1a0,000 payoff, but it was confirmed today that she had to sign a confidentiality agreement. Zoe conway, bbc news. If you are suffering distress or despair and need support, a list of organisations that can help is available at bbc. Co. Uk actionline, or you can call forfree on 0800 066 066. A 13 Year Old Girl has been remanded to Youth Detention Accommodation after being charged with three counts of attempted murder, after two teachers and a pupil were stabbed at a school in south west wales. Police said the teenager was arrested at the school in ammanford in carmarthenshire. The teachers and pupil were taken to hospital with non life threatening stab wounds, and have since been discharged. Two men who were arrested after five people died trying to cross the channel in a small boat earlier this week have been charged with immigration offences. Yien both from south sudan, and Tajdeen Adbulazinuma from sudan, are due to appear before Folkestone Magistrates Court today. An 18 year old man from sudan has been bailed pending further enquiries. A baby whom we filmed earlier in the week being rescued from her dying mothers womb after an israeli air strike in Southern Gaza has died. Baby Sabreen Al Sakani was delivered by Caesarean Section in a hospital in rafah shortly after midnight on sunday. Our correspondent, fergal keane, sent this update from jerusalem. Well, we got the news late last night in a phone call from an uncle of baby sabreen, who said that she had died yesterday morning and the family had buried her by 1pm. Now, this story begins last Saturday Night with an israeli air strike on the family home. The Israel Defence forces say they were going after hamas operatives and hamas infrastructure. The missile hit the family home. It killed sabreens father. It killed her three year old sister, malak, and then her mother, badly injured, was rushed to a local hospital, and thats where we saw these dramatic scenes of baby sabreen being born. She was born through a Caesarean Section on her mother, and then doctors tried to resuscitate her, tapping her chest to stimulate breathing, putting an air pump into her mouth and then placing her in an incubator, and it looked at that time as though there was a fragment of hope, that out of this terrible tragedy, some life would survive. Of course, at that time, we should point out, doctors were saying her condition was critical. And indeed, one of the doctors, dr salama, who looks after the Emergency Care in the Neonatal Unit at emirati hospital, he did say, if she survives. Well, we now know that that didnt happen. Baby sabreen joins the 16 other children who were killed that weekend in air strikes by israel. Were told also by Family Members that they would have been more than willing and were indeed happy at the prospect of adopting her. Mirvat al sakani, the maternal grandmother of baby sabreen, when ourjournalist colleague visited her in the refugee tent where shes living, she was scrolling through photographs of her daughter, speaking directly to her daughter and promising that she would take care of the child, along with the paternal grandmother, and also saying in that interview that she did with us, well, you will see baby sabreen in heaven. This is how the story ends, im sad to say baby sabreen dying, doctors doing their very best to try and save her, but not being successful. Our correspondent fergal keane reporting there. Scotlands First Minister humza yousaf is considering his next moves after ending the Power Sharing Agreement with the scottish greens. He now faces a vote of No Confidence. The greens said they would vote against mr yousaf, meaning his survival may depend on the vote of his former colleague ash regan, who defected from the snp to the Alba Party Last year. Our scotland correspondent, lorna gordon, is in dundee where mr yousaf has been speaking. How do things done for him . In the last few minutes, how do things done for him . In the last few minutes, humza how do things done for him . In the last few minutes, humza yousaf i how do things done for him . In the | last few minutes, humza yousaf has how do things done for him . In the i last few minutes, humza yousaf has a right this Housing Development in dundee. He ignored brutal question from the Waiting Media about he would continue as First Minister, whether he was a lame duck First Minister, but we are told he will do interviews later. He is trying to reset his government by making this announcement about affordable housing. But to be honest, all focus is on his future. We are told he will not be announcing his resignation today, despite speculation overnight about his future. But as he was travelling here came the news that he is facing notjust here came the news that he is facing not just one, here came the news that he is facing notjust one, but two votes of No Confidence. Yesterday, the conservatives tabled that motion of No Confidence in him and this morning, labourtabled No Confidence in him and this morning, labour tabled a motion of No Confidence in the snp government. They have said it is untenable for the snp to assume it can impose another unelected First Minister in scotland and it should be for the people of scotland to decide who is First Minister, notjust the snp. So it looks likely that humza yousaf will face two votes of confidence at some point next week, perhaps as early as wednesday. In the meantime, he has to get either the greens or ash regan, who lost out to him in the snp leadership contest, on board in order to survive. In order to survive. Lorna gordon reporting two british men have been charged with helping russia after a suspected attack on a ukrainian linked business. They are the