Projects, including livestock farming and agricultural processing. The government will have to inform about the results of joint work once every six months. The vologda region has become an important support for belarus in the northwest of russia in promoting, first of all, engineering products. Your own commodity Distribution Network structures have been formed, Assembly Production is functioning in bazerevetskoye, your metalworking is well developed, which means there is definitely a need to update the machine park, but in general, to be honest, we are somehow marking time in this regard, im sure you understand this , no worse me, if cooperation through belazeval is working well, then for the market area, but so far our manufacturers have not been able to work effectively in participating in tenders and so on. And today an agreement on trade, economic , scientific, technical and sociocultural cooperation has already been signed between belarus and the vologda region. A meeting of the joint commission on developing relations between regions was held in the capital. The result is a contract between mtz and the cherepovets foundry and mechanical plant for the supply. Plus a number of agreements on regional cooperation. We talked about the creation of several areas, the main directions of our work, this is agriculture, this is deep forest processing, this is mechanical engineering, this is strengthening interaction with the largest flagships, from belarus and from the russian federation, such as severstal, phosagro, ankador, mtz , mass, and many, many projects that we have recorded today, on which we will work. Issues of strengthening business cooperation, tourist exchanges, cultural interaction between the republic of belarus and the vologda region. At the end of 2022 , the vologda region ranks thirteenth in trade turnover with belarus among russian regions, ninth in imports and seventeenth in exports. In januaryaugust this year, the export growth rate was over 110 . Ukraine continues to fall out of the Global Information agenda in the United States. Republican senators introduced a bill to split the financial aid. According to the wall street journal, according to a separate bill, billions of dollars in aid will be transferred to israel, not kiev, called fools by supporters of american aid to ukraine, and billionaire elon musk. The entrepreneur supported the opinion of businessman david sachs, who recalled that last year washington gave kiev more than 100 billion for a successful offensive in the armed forces of ukraine, but this did not help. The escalation of the situation in the middle east continues to result in mass demonstrations around the world. A largescale protest in support of palestine broke out in tunisia. Protesters demand to stop bombing in the gas sector, the posters feature portraits of western politicians whom activists call murderers. I have everything by this time, see you at 19 00. It is to this process that the peacock owes the beauty of the color of its tail. The depth of eye color in humans and any animal is also his merit, and to be more precise, the special cells that ensure this process, everything would be fine, if not for one thing, for the beauty of the color of their hair, the aristocratic. Pallor of the skin or on the contrary, a golden tan, we say thank you. But the spots that appear after sunbathing, especially on the face, we try in every possible way to remove, im talking , of course, about pigment spots, well look at this problem in the next half hour and once again make sure that even when it comes to the natural processes of the body, science also nearby. At the studio ekaterina beretskaya, hello. And we begin, when does a person begin to produce pigment, which is responsible for the uniform complexion of the skin, and what happens if this system fails, risk groups, who should definitely strengthen sun protection, not using the ultraviolet spectrum of protection in the proper amount, injures the skin and stimulates. Melanocytes. And a new look at the problem from belarusian geneticists. We offer an assessment of peoples genetic predisposition to hyperpigmentation and photoaging. Pigmentation, in scientific terms, is the coloring of tissues and organs of a living organism in a certain color, due to the deposition of one or another dye in them. Substances. It is this process that determines the color of human skin and as a consequence, its tendency to form dark or light spots of the epidermis, as we will understand right now. It is almost impossible to find out what the skin color of the most ancient man was. Anthropologists suggest that millions of years ago, the light skin on the human body was protected by. The socalled coat. Evolving, populating different parts of the earth, people lost this very coat, and the body began to produce melanin, a dark brown pigment that protects us from ultraviolet radiation. Geneticists have come to the conclusion that quite quickly people who settled africa approximately 40,000 years ago acquired a dark skin tone. This indicates the production of melanin in sufficient quantities for those climatic conditions. But the people who came. In northern europe, where there is very little sunlight, almost 8,000 years ago, people had the gene for blue eyes and light skin. Today , the amount of melanin in the human body is no longer of interest to anthropologists, but to dermatologists, since the appearance of age spots depends on it. For example, excess melanin provokes hyperpigmentation, and moreover, contributes to the development of dermatological problems such as sunburn and melasma, these are. Spots on the skin, ephilides are freckles, but if melanin is produced in insufficient quantities, then white spots appear on the skin, doctors call this process depigmentation. Most often, pigment spots do not cause any discomfort to a person; it is only an aesthetic issue. Thats why our guest today is dermatovi. Neurologist, a specialist who every day makes patients faces beautiful. Natalya, hello. Good morning, ekaterina. Natalya, let s start with the types of pigment spots, because, as it turned out, they are different and even have different names. Of course, the variety of pigment spots is very large, and we must understand that we acquire some of them at birth, which is why they are called congenital, and some of them are our inheritance during life, pigment spots are a general concept, dyschromia, combine the concept of hypomelanosis, that is, complete or partial loss of pigment, and hypermelanosis this is excessive accumulation of melanin in certain layers of the skin, pigment spots will vary in size, the smallest of them are ephelides or freckles, which are probably inherent in almost every one of us, and the lighter the skin, the more of them there will be, then solar linting is a production process. In response to ultraviolet radiation, melasma, as a result of hormonal, stress or some other pathological changes, there may be toxic pigment spots, and of course we must remember that pigment spots can be traumatic nature, due to some aggressive mechanical, physical or chemical impact , that is, even so, even so, our skin can react with a pigment spot, of course, but the main character of the whole. I understand correctly, yes, lets figure out why in principle, they appear, yes, we talked about the types, yes, but not for everyone, just for some. This is a standard person who is already used to it, yes, but some people didnt have, there werent pigment spots there until a certain age, here on you, when you come back from vacation, you understand, that what you have on your face is not at all what you wanted, that is, i understand that many, many factors or a provocateur in this situation can be anything, of course, excessive insolation, excessive exposure of the skin to sunlight, especially in aggressive. Time of day, we say that safe tanning time is before 10 30 and after 16 hours, but our beaches demonstrate a different situation, as well as failure to use the ultraviolet spectrum of protection in the proper amount, injures the skin and stimulates melanocytes, because tanning is a protective reaction of the skin in response to ultraviolet irradiation, but there are a great many other processes that contribute to the appearance of hyperpigmentation. These are endocrine pathologies, this is a decrease or vice versa, excessive function of renal hormones, this is sleeps disease or hypercortisolism accompanying cuschengoid, this is hyperthyroidism, this is again a violation of glucose tolerance or a disorder of the metabolism of simple carbohydrates, diabetes mellitus or prediabetes, but this is a more complex endocrinological pathologies, as for our dermatological hyperpigmentation, they can be. Posttraumatic as a result of an incorrectly performed or incorrectly observed postprocedural period in cosmetic or dermatological manipulations. Aggressive damage to the skin, reduces its barrier functions and stimulates melanocytes. Therefore, if patients undergo chemical peels or laser resurfacing, they must definitely endure this period of skin restoration and protect it during this period. As much as possible if we are talking about hormonal hyperpigmentation, women are more often susceptible to it, melasma often accompanies pregnant girls, yes, this is all connected with changes in the synthesis of estrogen , in addition, liver function and bile flow are important here, and of course, as a flagship this is stress, and those same adrenal glands, which again are involved and thus stimulate the production of melanin, stress, and here, too , stress can be to blame, all diseases are from nerves, but good, but still, there are people who, in principle, never have this it happens, but there are people who have a regular history of this, they have already gotten used to it, lets say, a predisposition, that is, there is certainly some kind of genetic predisposition that determines the process of melanin synthesis, we can intervene by accelerating the reaction of melanocytes, but intervene for in order to reduce sensitivity, it is much more difficult, since we are talking about geneticists, just the latest research by our scientists, our academy of sciences, is devoted to the problem of pigmentation, the skin and the way to combat it, all the details are in the material of my colleagues. Lets go on a trip to belarus. Lyubansky district. Place to live, green, cozy, quiet. The kalibava romny highway gave impetus to the development of many settlements, including red. Its true that in order to get to the krynychka, you definitely need to do it on foot, well, its hard to get there. Together with us, you will receive a charge of positive emotions. Its such a cool feeling. It seems to me that i even saw a rainbow and i felt like a bird. Look at me. Look, pay attention, here is such a goat, between us she gets paid, well, theres always a pack of crackers, visit the bright sights of our country, tourists from all over the country come here to try the unique belarusian bread, 33 steps separate believers from the earthly to the sublime, they symbolize the life span of jesus christ, they say you can overcome this distance in in one breath, look in the program the route was built on the tv channel belarus 24. The west and the United States have taken seriously the cultivation of such a tool as radical nationalism, well and of course inciting national conflicts. This is what we got for our investments we did not lose a single american soldier, we reduced the combat power of the russian army by. We are exactly in the zone of contact between the conditionally collective west and the collective east, it is fundamentally important for us that this confrontation on our territory did not turn into a burning military against. The project is objective, dont miss new episodes on tv channel belarus 244. One of the most noticeable signs of photoaging the same hyperpigmentation, and in order not to lead to a visible problem, our geneticists have developed a special screening , we offer an assessment of the genetic predisposition of people to hyperpigmentation and photoaging, hyperpigmentation is one of the most important manifestations of photoaging, and we study a complex of five genes , which are mainly responsible for the synthesis of melanin in the skin, and also for skin regeneration and, well, a violation of its elasticity. Basically, that is, photoaging includes the main signs of hyperpigmentation, this is a violation of the transparency of the skin, the formation of rather deep wrinkles, they are a little different than those wrinkles that form during normal chronoaging, well. Which happens with age. All these signs, as a rule, begin to appear after 30 years, and if there is a genetic predisposition to pigmentation, then they can occur earlier. Based on the results of the analysis, we can find out whether a person has an increased risk of developing hyperpigmentation and, accordingly, signs of photoaging. This information will help cosmetologists and dermatologists optimize patient management tactics and select the most appropriate ones. Techniques, some approaches. This Genetic Information is also needed to organize timely preventive measures. For example, if a person finds himself in a risk zone, he will need to control the time he spends under the sun, and sometimes not appear in direct rays at all. And of course, exclude visiting the solarium. It is also recommended to use sunscreens and not only in summer, all year round, in accordance with your skin type, and do not forget to renew them in a timely manner, it is also recommended to quit smoking and change your diet in the direction of adding more substances containing antioxidants and treating inflammatory diseases, if relevant. Of course, first of all, people who already have visible problems will be interested in this genetic research, however, as geneticists say, even if they do not exist, this does not mean that after thirty or after 40 years, they will not appear. So to all people who take care of their skin, its better to do this analysis, especially since its result will never change, you only need to carry out the analysis once, as a rule, at least one risk factor is present in a person, but here it turns out that, in principle, the more of these risk genotypes, the risk of adverse effects of ultraviolet light and the risk of burns, as for how we have been doing this for a long time, this service. Appeared with us about a year ago, that is, we launched in september 2022 , it turns out that this was a complex of analyzes aimed at studying genetic features that are responsible for the beauty of skin and hair, but this is one of the directions, since we are studying five genes, the duration of the analysis is a maximum of 20 days, this genetic testing costs a little less than 200 rubles, but if you do several at once. We also have inflammatory diseases and androgenetic alopecia , that is, in areas regarding beauty, as for the application of these results, i would really like to tell you that, for example, if this is relevant, it is recommended carry out antiinflammatory treatment for people who have problems with inflammatory skin diseases, such as window rashes, for example, and they have unfavorable genotypes, for example, they are not recommended to use ultraviolet radiation to treat these inflammations, that is, this is important in order to somehow relevantly and correctly select treatment, or for example, there is such a phenomenon as hyperpigmentation, which is caused by the action of physical or chemical factors, that is , for example, with hyperpigmentation this is one of the negative side effects of such side effects, after carrying out procedures such as chemical peels or laser hair removal, that is, or some kind of laser therapy, there for the removal of moles there with blood vessels, when problems are solved, accordingly, it is worth, for example, undergoing genetic testing to know , are there risk genotypes for these genes, and if they are, then these procedures should be carried out with great caution, or it is possible to refuse to carry them out altogether, in any case, such genetic testing is excellent investing in the health of your skin. You are watching the science project nearby and heres Something Else well talk about today. When the manifestation of melasma is only a consequence of what diseases can facial skin signal . If they begin to itch, im now talking about nevi, and changing their color, changing their shape, of course, this is a signal, an alarm button in order to see a dermatologist or even a dermatooncologist. The best remedy is a hat to keep a roof over your head at noon, the most effective methods for preventing the appearance of age spots. And what to do if still did they appear, and even on the face . Belarus is a country with a rich and interesting history. Vos geta pabudova, yana. Illuminated by the punishment of mindaug, the first caravan of punishment, to whom our presentday land appeared, this kalegium of the educational establishment of the 16th century, such was the case throughout all of belarus, education was free, unique sights are found literally at every step y, church of the holy apostles peter and paul, also when entering it, you can literally touch the antiquity, you will see the traditional production of grain medicine, such pharmacies, which are there, you dont know, navat in the postsavetsky space, and the soul of the blueeyed people are people, hello, good afternoon to you, dear gasts, our shchyrae vitanna, we bring you, travel with us on the tv channel belarus 24. We live our lives , uh, according to their own laws, with their own traditions, but why should someone interfere in the internal affairs of our country, they believed that they could enslave russia and seize its resources, a huge market, enormous natural wealth. And they will live for another 300400 years so that the european to chase a multinational russian , you need to deprive him of his memory of what all the previous problems led to, the cossacks in paris, and these ones, thats why the monuments need to be removed, because these are the conditions for a future war. Today, a huge number of people come to us from different countries, how much they fall in love with our native belarus, they leave with the kindest thoughts for the country, so whoever wants to live and work, please, markovs project is nothing personal, watch it on the belarus 24 tv channel, but we are in studios with a specialist, dermatovenerog, we continue to understand the problem of pigmentation. Natalya, did they say in the first part that the cause of the appearance of age spots could be diseases, that is, this is, lets say, a signal from our skin, go to the doctor and get checked before you start simply removing this whole story . Everything is much more complicated if we clearly cannot find a trigger, a provoking factor, that is , we did not damage our skin. We didnt get burned by the sun, and we didnt apply any external chemical irritants, what if we pigment spots appeared, or even after damage, the appearance of your pigment spots changed greatly, they began to increase, and worse , even if they began to itch, im now talking about nevi, and changing their color, changing their shape, of course, this is a signal, an alarm button in order to refer. To an appointment with a dermatologist or even a dermatooncologist, because we are