Bruker and Evosep announce major progress in unbiased, quantitative true single-cell proteomics Bruker Corporation and Evosep today announced major progress in high-sensitivity, quantitative true single-cell proteomics, using a modified timsTOF Pro mass spectrometer connected to an Evosep One low-flow chromatography system. Evosep One is a chromatography system that delivers fast, sensitive and robust proteomic analysis of clinical samples, while supporting connections to a wide range of mass spectrometers. These advances have been demonstrated by the Mann-group in a paper by A. Brunner et al., which is now available on Bioarchive here. Key results include the first untargeted and unbiased analysis of true single cells achieving an identification depth of up to 1,500 protein groups from single FACS-sorted and individually digested HeLa cells. This remarkable sensitivity was achieved by the combined