This comprehensive article guides OSH professionals in developing robust Personal Protective Equipment (PPE) programs in compliance with OSHA's general duty clause. It covers the responsibilities of employers in hazard identification and mitigation, the use of the Hierarchy of Controls, and the critical steps in selecting and implementing PPE. The article emphasizes the importance of management commitment, worker participation, continuous assessment, and effective communication in establishing a successful PPE program that ensures workplace safety and adherence to regulatory standards.