CHOP Researchers Find Ribosome Assembly Essential for Stem Cell Regeneration --Findings enhance our understanding of the importance of ribosome assembly in stem cell regeneration and potential therapeutic strategies for ribosomopathies, which lead to pediatric bone marrow abnormalities-- News provided by Share this article Share this article PHILADELPHIA, March 11, 2021 /PRNewswire/ -- Researchers at Children's Hospital of Philadelphia (CHOP) have identified genes responsible for hematopoietic stem cell (HSC) regeneration via the assembly of the ribosome, the protein factories in cells that translate mRNA sequences into amino acid sequences. The findings, which were published in Cell Stem Cell, highlight the importance of proper ribosome assembly in stem cell regeneration and identify possible targets for future therapies for ribosomopathies, childhood disorders that lead to bone marrow failure (BMF).