Combining biochemical and topographical cues improves quality of skeletal muscle regeneration When trauma, illness, or injury causes significant muscle loss, reconstructive procedures for bioengineering functional skeletal muscles can fall short, resulting in permanent impairments. Finding a synergy in the importance of biochemical signals and topographical cues, researchers from Wake Forest Institute for Regenerative Medicine, Sungkyunkwan University, and Chonnam National University developed an efficient technique for muscle regeneration and functional restoration in injured rats. They describe results from the technique in the journal Applied Physics Reviews, from AIP Publishing. The group expanded on a method they previously developed using muscle-specific materials derived from an organism's tissues (dECM-MA) to construct bioinks, which are materials used for 3D-printing tissue.