May 19, 2021 Among patients at low risk for surgery, TAVI with the Evolut prosthetic valve (Medtronic) is noninferior to surgery with regard to the endpoint of death or disabling stroke at 2 years, according to additional data from the Evolut Low-Risk Trial. The findings strengthen the original results, presented at American College of Cardiology (ACC) 2019 meeting and simultaneously published in the New England Journal of Medicine, which showed noninferiority of TAVI compared with surgery for death and disabling stroke at 24 months in a Bayesian analysis once 850 of the 1,414 enrolled patients had reached 12-month follow-up. In the complete analysis, presented by John Forrest, MD (Yale School of Medicine, New Haven, CT), yesterday at EuroPCR 2021, all patients had completed 2-year follow-up, representing 97.3% and 92.3% of the patients originally randomized to TAVI and surgery, respectively. Longer-term follow-up will evaluate patient endpoints out to 10 years, said Forrest.